Behavioural and neurochemical adaptations to nicotine in rats: influence of NMDA antagonists

1 The repeated co‐administration of the non‐competitive N‐methyl‐d‐aspartate (NMDA) receptor antagonist dizocilpine (0.1 and 0.3 mg kg−1, i.p.) with nicotine (0.4 mg kg−1, s.c.) attenuated the development of tolerance to the locomotor depressant effect of the nicotine in rats. 2 The repeated co‐admi...

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Veröffentlicht in:	British journal of pharmacology 1994-04, Vol.111 (4), p.1073-1080
Hauptverfasser:	Shoaib, M., Benwell, M.E.M., Akbar, M.T., Stolerman, I.P., Balfour, D.J.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Chemistry - drug effects dizocilpine Dizocilpine Maleate - pharmacology Dopamine - analysis Dopamine - metabolism Drug Tolerance d‐CPPene extracellular dopamine locomotor activity Male Medical sciences MK‐801 Motor Activity - drug effects Nicotine Nicotine - pharmacology NMDA receptor antagonists Piperazines - pharmacology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, Nicotinic - drug effects SDZ EAA 494 Tobacco, tobacco smoking Toxicology
Online-Zugang:	Volltext
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