Natriuretic action of angiotensin(1–7)
Evidence that angiotensin (1–7) (Ang(1–7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentrati...
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| Veröffentlicht in: | British journal of pharmacology 1994-01, Vol.111 (1), p.1-3 |
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| creator | DelliPizzi, AnnMarie Hilchey, Sean D. Bell‐Quilley, Caroline P. |
| description | Evidence that angiotensin (1–7) (Ang(1–7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1–7) may participate in the renal effects of the renin‐angiotensin system. |
| doi_str_mv | 10.1111/j.1476-5381.1994.tb14014.x |
| format | Article |
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Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1–7) may participate in the renal effects of the renin‐angiotensin system.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1994.tb14014.x</identifier><identifier>PMID: 8012686</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Angiotensin (1–7) ; Angiotensin I ; angiotensin II ; Angiotensin II - pharmacology ; Animals ; Biological and medical sciences ; Diuresis - drug effects ; electrolyte excretion ; Endocrine kidney. Renin-angiotensin-aldosterone system ; Fundamental and applied biological sciences. 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Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1–7) may participate in the renal effects of the renin‐angiotensin system.</description><subject>Angiotensin (1–7)</subject><subject>Angiotensin I</subject><subject>angiotensin II</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diuresis - drug effects</subject><subject>electrolyte excretion</subject><subject>Endocrine kidney. Renin-angiotensin-aldosterone system</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GFR</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Kidney - blood supply</subject><subject>Kidney - drug effects</subject><subject>Kidney Tubules - drug effects</subject><subject>Male</subject><subject>Natriuresis - drug effects</subject><subject>Peptide Fragments - pharmacology</subject><subject>rat isolated kidney</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vascular Resistance - drug effects</subject><subject>Vertebrates: endocrinology</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1KxDAUhYMoOv48gjCIiC5ab5q0SV2IOvgHoi50HW4zqWbotGPSUWfnO_iGPomtUwZdms0NnO_ecziE7FAIafMORyHlIgliJmlI05SHdUY5UB6-L5HeQlomPQAQAaVSrpF170fQMELEq2RVAo0SmfTI_i3Wzk6dqa3uo65tVfarvI_lk61qU3pb7tOvj09xsElWciy82ermBnm8OH8YXAU3d5fXg9ObQMeC8SBHrjMwEeYoIM6GWWMDMhYmSvMMkzgxMeSQRK0_15JRNjQgMWIpZwnKiG2Q4_ndyTQbm6E2Ze2wUBNnx-hmqkKr_iqlfVZP1auiKQWI2gN73QFXvUyNr9XYem2KAktTTb0STYiEibgBj-agdpX3zuQLEwqq7VmNVFumastUbc-q61m9N8vbv2MuVrtiG32309FrLHKHpbZ-gbEUpOSswU7m2JstzOwfAdTZ_dXPl30DOZSaaQ</recordid><startdate>199401</startdate><enddate>199401</enddate><creator>DelliPizzi, AnnMarie</creator><creator>Hilchey, Sean D.</creator><creator>Bell‐Quilley, Caroline P.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199401</creationdate><title>Natriuretic action of angiotensin(1–7)</title><author>DelliPizzi, AnnMarie ; Hilchey, Sean D. ; Bell‐Quilley, Caroline P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5734-fa4cb0e2afa705bdb2680857e29fba656e50f06201264c8313de08a239436a823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Angiotensin (1–7)</topic><topic>Angiotensin I</topic><topic>angiotensin II</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diuresis - drug effects</topic><topic>electrolyte excretion</topic><topic>Endocrine kidney. Renin-angiotensin-aldosterone system</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GFR</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Kidney - blood supply</topic><topic>Kidney - drug effects</topic><topic>Kidney Tubules - drug effects</topic><topic>Male</topic><topic>Natriuresis - drug effects</topic><topic>Peptide Fragments - pharmacology</topic><topic>rat isolated kidney</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vascular Resistance - drug effects</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DelliPizzi, AnnMarie</creatorcontrib><creatorcontrib>Hilchey, Sean D.</creatorcontrib><creatorcontrib>Bell‐Quilley, Caroline P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DelliPizzi, AnnMarie</au><au>Hilchey, Sean D.</au><au>Bell‐Quilley, Caroline P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natriuretic action of angiotensin(1–7)</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1994-01</date><risdate>1994</risdate><volume>111</volume><issue>1</issue><spage>1</spage><epage>3</epage><pages>1-3</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>Evidence that angiotensin (1–7) (Ang(1–7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration and (3) an increase in glomerular filtration rate without affecting renal vascular resistance. Thus, Ang(1–7) may participate in the renal effects of the renin‐angiotensin system.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8012686</pmid><doi>10.1111/j.1476-5381.1994.tb14014.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiotensin (1–7) Angiotensin I angiotensin II Angiotensin II - pharmacology Animals Biological and medical sciences Diuresis - drug effects electrolyte excretion Endocrine kidney. Renin-angiotensin-aldosterone system Fundamental and applied biological sciences. Psychology GFR Glomerular Filtration Rate - drug effects Kidney - blood supply Kidney - drug effects Kidney Tubules - drug effects Male Natriuresis - drug effects Peptide Fragments - pharmacology rat isolated kidney Rats Rats, Sprague-Dawley Vascular Resistance - drug effects Vertebrates: endocrinology |
| title | Natriuretic action of angiotensin(1–7) |
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