Evidence for an inhibitory 5‐HT4 receptor in urinary bladder of Rhesus and Cynomolgus monkeys

1 The present study shows that 5‐hydroxytryptamine (5‐HT) inhibits electrically‐evoked contractions of isolated urinary bladder strips from Rhesus and Cynomolgus monkeys via activation of 5‐HT4 receptors. 2 5‐HT (0.1 nM‐10 μm) produced concentration‐dependent inhibition of the contractile response t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of pharmacology 1994-01, Vol.111 (1), p.213-218
Hauptverfasser:	Waikar, Manoj V., Ford, Anthony P.D.W., Clarke, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT 5‐HT4 receptor 5‐methoxytryptamine Animals BIMU 8 Biological and medical sciences Cynomolgus monkey DAU 6285 Dose-Response Relationship, Drug Electric Stimulation Female Fundamental and applied biological sciences. Psychology GR 113808 In Vitro Techniques Macaca fascicularis Macaca mulatta Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Receptors, Serotonin - physiology Rhesus monkey RS 23597–190 Serotonin - pharmacology Serotonin Antagonists - metabolism Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - metabolism Serotonin Receptor Agonists - pharmacology Urinary Bladder - drug effects Urinary Bladder - physiology urinary bladder of monkey Vertebrates: urinary system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!