Inhibition by SK&F96365 of NO‐mediated relaxation induced by Ca2+ ‐ATPase inhibitors in rat thoracic aorta

1 We investigated the effect of SK&F96365, a putative inhibitor of receptor‐operated Ca2+ entry, on the endothelium‐dependent, NO‐mediated relaxation and cyclic GMP formation induced by Ca2+‐ATPase inhibitors in rat thoracic aorta. 2 SK&F96365 inhibited cyclopiazonic acid or thapsigargin‐ind...

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Veröffentlicht in:	British journal of pharmacology 1996-04, Vol.117 (7), p.1544-1548
Hauptverfasser:	Moritoki, Hideki, Hisayama, Tetsuhiro, Takeuchi, Shougo, Kondoh, Wataru, Inoue, Shinnichi, Kida, Kan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aorta Aorta, Thoracic - metabolism Biological and medical sciences Ca2+ influx Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium-Transporting ATPases - antagonists & inhibitors Cyclic GMP - biosynthesis cyclopiazonic acid endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Imidazoles - pharmacology In Vitro Techniques Indoles - pharmacology Male Medical sciences Muscle Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Nickel - pharmacology Nitric Oxide - antagonists & inhibitors Nitric Oxide - physiology NO formation Pharmacology. Drug treatments Rats Rats, Wistar relaxation SK&F96365 Terpenes - pharmacology Thapsigargin
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