Neuromuscular blocking profile of the vecuronium analogue, Org‐9487, in the rat isolated hemidiaphragm preparation

1 The neuromuscular effects of the short‐acting aminosteroid muscle relaxant Org‐9487 have been studied in the in vitro rat phrenic nerve/hemidiaphragm preparation by use of twitch tension and electrophysiological recording techniques. 2 Org‐9487 (5–100 μm) produced a concentration‐dependent decreas...

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Veröffentlicht in:	British journal of pharmacology 1995-12, Vol.116 (7), p.3049-3055
Hauptverfasser:	Prior, Chris, Tian, Lijun, Mallah, Ahmed I. El, Young, Louise, Ward, Joanna M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholinesterase - metabolism Anesthetics. Neuromuscular blocking agents Animals anticholinesterase Biological and medical sciences Diaphragm - drug effects Diaphragm - innervation Electric Stimulation endplate currents In Vitro Techniques Ion Channels - drug effects Male Medical sciences Motor Endplate - drug effects Motor Endplate - metabolism Muscle Contraction - drug effects Neuromuscular Junction - drug effects Neuromuscular Nondepolarizing Agents - pharmacology neuromuscular transmission Neuropharmacology Org‐9487 Pharmacology. Drug treatments Phrenic Nerve - drug effects rat phrenic nerve/hemidiaphragm Rats Rats, Sprague-Dawley Vecuronium Bromide - analogs & derivatives Vecuronium Bromide - pharmacology
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