Evidence that activation of 5‐HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation
1 The aim of the present experiments was to determine whether the effects of lateral ventricular application of 5‐HT on cardiovascular and respiratory variables in anaesthetized cats are mediated by forebrain 5‐HT2 receptors. This was carried out by determining whether the effects of 5‐HT are blocke...
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| Veröffentlicht in: | British journal of pharmacology 1995-09, Vol.116 (2), p.1751-1756 |
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| description | 1
The aim of the present experiments was to determine whether the effects of lateral ventricular application of 5‐HT on cardiovascular and respiratory variables in anaesthetized cats are mediated by forebrain 5‐HT2 receptors. This was carried out by determining whether the effects of 5‐HT are blocked by the 5‐HT2 antagonist, cinanserin and if they are mimicked by the selective 5‐HT2 agonist, 1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI)
2
Cats were anaesthetized with a mixture of oc‐chloralose and pentobarbitone sodium, neuromuscularly blocked and artificially ventilated. The following cardiovascular and respiratory variables were recorded: renal, splanchnic and cardiac sympathetic nerve activities, phrenic nerve activity, heart rate, arterial blood pressure, femoral arterial conductance and tracheal pressure. All drugs were administered via the lateral ventricle and the action of these agonists was restricted to forebrain sites by a cannula placed in the Aqueduct of Sylvius
3
Cumulative doses of 5‐HT (10–160 nmol kg−1) and DOI (80–320 nmol kg−1) injected into the lateral ventricle caused significant increases in blood pressure, heart rate, cardiac and splanchnic sympathetic nerve activity and a decrease in femoral arterial conductance. DOI and 5‐HT caused a greater increase in cardiac compared with splanchnic nerve activity and failed to change renal nerve activity
5
‐HT but not DOI significantly increased the magnitude and the number of phrenic bursts as well as significantly increasing tracheal pressure. The effects of 5‐HT also differed from DOI in that 5‐HT evoked maximal pressor and near maximal sympathoexcitatory effects after the first dose, whereas the pressor and sympathoexcitatory effects of DOI were graded over the complete dose‐range
4
The 5‐HT2 antagonist, cinanserin (265 nmol kg−1, i.c.v.) caused significant falls in blood pressure, heart rate and cardiac nerve activity and an increase in femoral arterial conductance. Splanchnic and renal sympathetic nerve activity, phrenic nerve activity and tracheal pressure were unaffected by cinanserin. After pretreatment with cinanserin all cardiovascular and respiratory effects of 5‐HT were significantly attenuated
5
It is concluded that in the cat, as DOI and 5‐HT have similar effects on the cardiovascular variables recorded and as the effects of 5‐HT are blocked by cinanserin, 5‐HT can act on 5‐HT2 receptors located in the forebrain to cause differential sympathoexcitation and a rise in arteria |
| doi_str_mv | 10.1111/j.1476-5381.1995.tb16658.x |
| format | Article |
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The aim of the present experiments was to determine whether the effects of lateral ventricular application of 5‐HT on cardiovascular and respiratory variables in anaesthetized cats are mediated by forebrain 5‐HT2 receptors. This was carried out by determining whether the effects of 5‐HT are blocked by the 5‐HT2 antagonist, cinanserin and if they are mimicked by the selective 5‐HT2 agonist, 1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI)
2
Cats were anaesthetized with a mixture of oc‐chloralose and pentobarbitone sodium, neuromuscularly blocked and artificially ventilated. The following cardiovascular and respiratory variables were recorded: renal, splanchnic and cardiac sympathetic nerve activities, phrenic nerve activity, heart rate, arterial blood pressure, femoral arterial conductance and tracheal pressure. All drugs were administered via the lateral ventricle and the action of these agonists was restricted to forebrain sites by a cannula placed in the Aqueduct of Sylvius
3
Cumulative doses of 5‐HT (10–160 nmol kg−1) and DOI (80–320 nmol kg−1) injected into the lateral ventricle caused significant increases in blood pressure, heart rate, cardiac and splanchnic sympathetic nerve activity and a decrease in femoral arterial conductance. DOI and 5‐HT caused a greater increase in cardiac compared with splanchnic nerve activity and failed to change renal nerve activity
5
‐HT but not DOI significantly increased the magnitude and the number of phrenic bursts as well as significantly increasing tracheal pressure. The effects of 5‐HT also differed from DOI in that 5‐HT evoked maximal pressor and near maximal sympathoexcitatory effects after the first dose, whereas the pressor and sympathoexcitatory effects of DOI were graded over the complete dose‐range
4
The 5‐HT2 antagonist, cinanserin (265 nmol kg−1, i.c.v.) caused significant falls in blood pressure, heart rate and cardiac nerve activity and an increase in femoral arterial conductance. Splanchnic and renal sympathetic nerve activity, phrenic nerve activity and tracheal pressure were unaffected by cinanserin. After pretreatment with cinanserin all cardiovascular and respiratory effects of 5‐HT were significantly attenuated
5
It is concluded that in the cat, as DOI and 5‐HT have similar effects on the cardiovascular variables recorded and as the effects of 5‐HT are blocked by cinanserin, 5‐HT can act on 5‐HT2 receptors located in the forebrain to cause differential sympathoexcitation and a rise in arterial blood pressure. Further, the sympathoexcitatory effects mediated by 5‐HT2 receptors located in the forebrain differ from those located in the hindbrain in that they mediate increases in cardiac nerve activity and heart rate and also have no effect on renal nerve activity.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1995.tb16658.x</identifier><identifier>PMID: 8528555</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anesthesia ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cats ; Cell receptors ; Cell structures and functions ; Cinanserin - pharmacology ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Male ; Molecular and cellular biology ; Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) ; Prosencephalon - drug effects ; Receptors, Serotonin - drug effects ; Serotonin - pharmacology ; Sympathetic Nervous System - drug effects ; Time Factors</subject><ispartof>British journal of pharmacology, 1995-09, Vol.116 (2), p.1751-1756</ispartof><rights>1995 British Pharmacological Society</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1909073/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1909073/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3662066$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8528555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Ian K.</creatorcontrib><creatorcontrib>Martin, Graeme R.</creatorcontrib><creatorcontrib>Ramage, Andrew G.</creatorcontrib><title>Evidence that activation of 5‐HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
The aim of the present experiments was to determine whether the effects of lateral ventricular application of 5‐HT on cardiovascular and respiratory variables in anaesthetized cats are mediated by forebrain 5‐HT2 receptors. This was carried out by determining whether the effects of 5‐HT are blocked by the 5‐HT2 antagonist, cinanserin and if they are mimicked by the selective 5‐HT2 agonist, 1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI)
2
Cats were anaesthetized with a mixture of oc‐chloralose and pentobarbitone sodium, neuromuscularly blocked and artificially ventilated. The following cardiovascular and respiratory variables were recorded: renal, splanchnic and cardiac sympathetic nerve activities, phrenic nerve activity, heart rate, arterial blood pressure, femoral arterial conductance and tracheal pressure. All drugs were administered via the lateral ventricle and the action of these agonists was restricted to forebrain sites by a cannula placed in the Aqueduct of Sylvius
3
Cumulative doses of 5‐HT (10–160 nmol kg−1) and DOI (80–320 nmol kg−1) injected into the lateral ventricle caused significant increases in blood pressure, heart rate, cardiac and splanchnic sympathetic nerve activity and a decrease in femoral arterial conductance. DOI and 5‐HT caused a greater increase in cardiac compared with splanchnic nerve activity and failed to change renal nerve activity
5
‐HT but not DOI significantly increased the magnitude and the number of phrenic bursts as well as significantly increasing tracheal pressure. The effects of 5‐HT also differed from DOI in that 5‐HT evoked maximal pressor and near maximal sympathoexcitatory effects after the first dose, whereas the pressor and sympathoexcitatory effects of DOI were graded over the complete dose‐range
4
The 5‐HT2 antagonist, cinanserin (265 nmol kg−1, i.c.v.) caused significant falls in blood pressure, heart rate and cardiac nerve activity and an increase in femoral arterial conductance. Splanchnic and renal sympathetic nerve activity, phrenic nerve activity and tracheal pressure were unaffected by cinanserin. After pretreatment with cinanserin all cardiovascular and respiratory effects of 5‐HT were significantly attenuated
5
It is concluded that in the cat, as DOI and 5‐HT have similar effects on the cardiovascular variables recorded and as the effects of 5‐HT are blocked by cinanserin, 5‐HT can act on 5‐HT2 receptors located in the forebrain to cause differential sympathoexcitation and a rise in arterial blood pressure. Further, the sympathoexcitatory effects mediated by 5‐HT2 receptors located in the forebrain differ from those located in the hindbrain in that they mediate increases in cardiac nerve activity and heart rate and also have no effect on renal nerve activity.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cats</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cinanserin - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart Rate - drug effects</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</subject><subject>Prosencephalon - drug effects</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Serotonin - pharmacology</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Time Factors</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdFuFCEYhYmxqWv1EUyIMd7NCIPAcGOsTXVNmuhFvSYM84_LZnYYgV13vfIRfMY-icx2smm5gD98J-cEDkKvKSlpXu_WJX0vRcFZTUuqFC9TQ4Xgdbl_ghYn9BQtCCGyoLSun6HnMa4JyVDyc3Re86rmnC_QcL1zLQwWcFqZhI1NbmeS8wP2HeZ3f_8tbyscwMKYfIjYDVkHuPMBmmDcUWUGAzHfJvcHWmxNinnbRog4HjajSSsPe-vS0fUFOutMH-HlfF6gH5-vb6-Wxc23L1-vLm-KkSlVF0rwytrWSEEbVbMWeEOkEkQyakljK2YZKNMxRXlFuGhBtkoKrjgVUlEp2AX6cO87bpsNtBaGFEyvx-A2Jhy0N04_JoNb6Z9-p6kiKsdkg7ezQfC_tvl9euOihb43A_ht1FJKVjM2Jb16mHSKmH848zczN9GavgtmsC6eZEyIiojJ5uO97Lfr4XDClOipcb3WU616qlVPjeu5cb3Xn74vjyP7Dw3YowE</recordid><startdate>199509</startdate><enddate>199509</enddate><creator>Anderson, Ian K.</creator><creator>Martin, Graeme R.</creator><creator>Ramage, Andrew G.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199509</creationdate><title>Evidence that activation of 5‐HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation</title><author>Anderson, Ian K. ; Martin, Graeme R. ; Ramage, Andrew G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3998-9652ccda761b983de5b07960731c0bc23c3e9af39152056de7d97659516791763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cats</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cinanserin - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heart Rate - drug effects</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</topic><topic>Prosencephalon - drug effects</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Serotonin - pharmacology</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Ian K.</creatorcontrib><creatorcontrib>Martin, Graeme R.</creatorcontrib><creatorcontrib>Ramage, Andrew G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Ian K.</au><au>Martin, Graeme R.</au><au>Ramage, Andrew G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence that activation of 5‐HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1995-09</date><risdate>1995</risdate><volume>116</volume><issue>2</issue><spage>1751</spage><epage>1756</epage><pages>1751-1756</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
The aim of the present experiments was to determine whether the effects of lateral ventricular application of 5‐HT on cardiovascular and respiratory variables in anaesthetized cats are mediated by forebrain 5‐HT2 receptors. This was carried out by determining whether the effects of 5‐HT are blocked by the 5‐HT2 antagonist, cinanserin and if they are mimicked by the selective 5‐HT2 agonist, 1‐(2,5‐dimethoxy‐4‐iodophenyl)‐2‐aminopropane (DOI)
2
Cats were anaesthetized with a mixture of oc‐chloralose and pentobarbitone sodium, neuromuscularly blocked and artificially ventilated. The following cardiovascular and respiratory variables were recorded: renal, splanchnic and cardiac sympathetic nerve activities, phrenic nerve activity, heart rate, arterial blood pressure, femoral arterial conductance and tracheal pressure. All drugs were administered via the lateral ventricle and the action of these agonists was restricted to forebrain sites by a cannula placed in the Aqueduct of Sylvius
3
Cumulative doses of 5‐HT (10–160 nmol kg−1) and DOI (80–320 nmol kg−1) injected into the lateral ventricle caused significant increases in blood pressure, heart rate, cardiac and splanchnic sympathetic nerve activity and a decrease in femoral arterial conductance. DOI and 5‐HT caused a greater increase in cardiac compared with splanchnic nerve activity and failed to change renal nerve activity
5
‐HT but not DOI significantly increased the magnitude and the number of phrenic bursts as well as significantly increasing tracheal pressure. The effects of 5‐HT also differed from DOI in that 5‐HT evoked maximal pressor and near maximal sympathoexcitatory effects after the first dose, whereas the pressor and sympathoexcitatory effects of DOI were graded over the complete dose‐range
4
The 5‐HT2 antagonist, cinanserin (265 nmol kg−1, i.c.v.) caused significant falls in blood pressure, heart rate and cardiac nerve activity and an increase in femoral arterial conductance. Splanchnic and renal sympathetic nerve activity, phrenic nerve activity and tracheal pressure were unaffected by cinanserin. After pretreatment with cinanserin all cardiovascular and respiratory effects of 5‐HT were significantly attenuated
5
It is concluded that in the cat, as DOI and 5‐HT have similar effects on the cardiovascular variables recorded and as the effects of 5‐HT are blocked by cinanserin, 5‐HT can act on 5‐HT2 receptors located in the forebrain to cause differential sympathoexcitation and a rise in arterial blood pressure. Further, the sympathoexcitatory effects mediated by 5‐HT2 receptors located in the forebrain differ from those located in the hindbrain in that they mediate increases in cardiac nerve activity and heart rate and also have no effect on renal nerve activity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8528555</pmid><doi>10.1111/j.1476-5381.1995.tb16658.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia Animals Biological and medical sciences Blood Pressure - drug effects Cats Cell receptors Cell structures and functions Cinanserin - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Male Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Prosencephalon - drug effects Receptors, Serotonin - drug effects Serotonin - pharmacology Sympathetic Nervous System - drug effects Time Factors |
| title | Evidence that activation of 5‐HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation |
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