Effect of treatment with vitamin D3 on the responses of the duodenum of spontaneously hypertensive rats to bradykinin and to potassium
1 The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto (WKY) and Wistar (NWR) rats was supplemented with either 2% calcium lactate in the drinking water or 12.5 μg vitamin D3 100 g−1 body weight daily by gavage, for 14 days. 2 The blood pressure of the SHR treated with eit...
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| Veröffentlicht in: | British journal of pharmacology 1992-04, Vol.105 (4), p.881-884 |
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| container_title | British journal of pharmacology |
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| creator | Feres, Teresa Vianna, Lucia M. Paiva, Antonio C.M. Therezinha Paiva, B. |
| description | 1
The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto (WKY) and Wistar (NWR) rats was supplemented with either 2% calcium lactate in the drinking water or 12.5 μg vitamin D3 100 g−1 body weight daily by gavage, for 14 days.
2
The blood pressure of the SHR treated with either calcium or vitamin D decreased to the same levels as that of WKY and NWR.
3
The response to bradykinin of the SHR isolated duodenum, which is predominantly contractile, upon treatment with vitamin D (but not with calcium), became predominantly relaxant, approaching the normal behaviour of the WKY and NWR duodenum.
4
The relaxant responses of the SHR and WKY duodenum to potassium were smaller than those of NWR, but treatment with vitamin D increased the response in all three rat strains.
5
It is concluded that, besides sharing the hypotensive effect of calcium, vitamin D treatment of SHR has an effect on the duodenum smooth muscle which might be due to calmodulin‐dependent activation of calcium‐dependent potassium channels. |
| doi_str_mv | 10.1111/j.1476-5381.1992.tb09072.x |
| format | Article |
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The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto (WKY) and Wistar (NWR) rats was supplemented with either 2% calcium lactate in the drinking water or 12.5 μg vitamin D3 100 g−1 body weight daily by gavage, for 14 days.
2
The blood pressure of the SHR treated with either calcium or vitamin D decreased to the same levels as that of WKY and NWR.
3
The response to bradykinin of the SHR isolated duodenum, which is predominantly contractile, upon treatment with vitamin D (but not with calcium), became predominantly relaxant, approaching the normal behaviour of the WKY and NWR duodenum.
4
The relaxant responses of the SHR and WKY duodenum to potassium were smaller than those of NWR, but treatment with vitamin D increased the response in all three rat strains.
5
It is concluded that, besides sharing the hypotensive effect of calcium, vitamin D treatment of SHR has an effect on the duodenum smooth muscle which might be due to calmodulin‐dependent activation of calcium‐dependent potassium channels.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1992.tb09072.x</identifier><identifier>PMID: 1324053</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Blood Pressure - drug effects ; Bradykinin ; Bradykinin - pharmacology ; Cholecalciferol - pharmacology ; duodenum ; Duodenum - drug effects ; Duodenum - physiology ; Female ; Hypertension - drug therapy ; Hypertension - physiopathology ; In Vitro Techniques ; intestinal smooth muscle ; Muscle Relaxation - drug effects ; Potassium - pharmacology ; Rats ; Rats, Inbred SHR ; Rats, Inbred Strains ; Rats, Inbred WKY ; spontaneously hypertensive rats ; vitamin D</subject><ispartof>British journal of pharmacology, 1992-04, Vol.105 (4), p.881-884</ispartof><rights>1992 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908699/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1908699/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1324053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feres, Teresa</creatorcontrib><creatorcontrib>Vianna, Lucia M.</creatorcontrib><creatorcontrib>Paiva, Antonio C.M.</creatorcontrib><creatorcontrib>Therezinha</creatorcontrib><creatorcontrib>Paiva, B.</creatorcontrib><title>Effect of treatment with vitamin D3 on the responses of the duodenum of spontaneously hypertensive rats to bradykinin and to potassium</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto (WKY) and Wistar (NWR) rats was supplemented with either 2% calcium lactate in the drinking water or 12.5 μg vitamin D3 100 g−1 body weight daily by gavage, for 14 days.
2
The blood pressure of the SHR treated with either calcium or vitamin D decreased to the same levels as that of WKY and NWR.
3
The response to bradykinin of the SHR isolated duodenum, which is predominantly contractile, upon treatment with vitamin D (but not with calcium), became predominantly relaxant, approaching the normal behaviour of the WKY and NWR duodenum.
4
The relaxant responses of the SHR and WKY duodenum to potassium were smaller than those of NWR, but treatment with vitamin D increased the response in all three rat strains.
5
It is concluded that, besides sharing the hypotensive effect of calcium, vitamin D treatment of SHR has an effect on the duodenum smooth muscle which might be due to calmodulin‐dependent activation of calcium‐dependent potassium channels.</description><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Bradykinin</subject><subject>Bradykinin - pharmacology</subject><subject>Cholecalciferol - pharmacology</subject><subject>duodenum</subject><subject>Duodenum - drug effects</subject><subject>Duodenum - physiology</subject><subject>Female</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>In Vitro Techniques</subject><subject>intestinal smooth muscle</subject><subject>Muscle Relaxation - drug effects</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Inbred WKY</subject><subject>spontaneously hypertensive rats</subject><subject>vitamin D</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi1EVbaFn4BkceCWMI7z5QsISr-kSnCAs-XEE9ZLYofY2TZ_oL8bh10V8GXsecbvePwS8oZByuJ6t0tZXpVJwWuWMiGyNDQgoMrSh2dk84Sekw0AVAljdf2CnHm_A4iwKk7JKeNZDgXfkMfLrsM2UNfRMKEKA9pA703Y0r0JajCWfubUWRq2SCf0o7Me_Z_qmNCz02jnYT2vKCiLbvb9QrfLiFNA680-3lPB0-BoMym9_DQ2iiqr18zogvLezMNLctKp3uOrYzwn368uv13cJHdfrm8vPt4lIy9FlmhdF43CsmE5aAVNjCWCEhxy0RZVHIrzplVY86pu8xZ1rTRmXFSgi1aLjp-T9wfdcW4G1G2cdlK9HCczqGmRThn5P7FmK3-4vWQC6lKIKPD2KDC5XzP6IAfjW-z7w-iy4vFpHHgsfP1vp6cWx5-P_MOB35sel78Y5Gqx3MnVR7n6KFeL5dFi-SA_fb1Zd_w3N-6gEA</recordid><startdate>199204</startdate><enddate>199204</enddate><creator>Feres, Teresa</creator><creator>Vianna, Lucia M.</creator><creator>Paiva, Antonio C.M.</creator><creator>Therezinha</creator><creator>Paiva, B.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199204</creationdate><title>Effect of treatment with vitamin D3 on the responses of the duodenum of spontaneously hypertensive rats to bradykinin and to potassium</title><author>Feres, Teresa ; Vianna, Lucia M. ; Paiva, Antonio C.M. ; Therezinha ; Paiva, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3692-dd85bae6b140da0bb146e0a93049c5732433bcae8378c4ced8ade23970d5cd9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Bradykinin</topic><topic>Bradykinin - pharmacology</topic><topic>Cholecalciferol - pharmacology</topic><topic>duodenum</topic><topic>Duodenum - drug effects</topic><topic>Duodenum - physiology</topic><topic>Female</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>In Vitro Techniques</topic><topic>intestinal smooth muscle</topic><topic>Muscle Relaxation - drug effects</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Inbred WKY</topic><topic>spontaneously hypertensive rats</topic><topic>vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feres, Teresa</creatorcontrib><creatorcontrib>Vianna, Lucia M.</creatorcontrib><creatorcontrib>Paiva, Antonio C.M.</creatorcontrib><creatorcontrib>Therezinha</creatorcontrib><creatorcontrib>Paiva, B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feres, Teresa</au><au>Vianna, Lucia M.</au><au>Paiva, Antonio C.M.</au><au>Therezinha</au><au>Paiva, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of treatment with vitamin D3 on the responses of the duodenum of spontaneously hypertensive rats to bradykinin and to potassium</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1992-04</date><risdate>1992</risdate><volume>105</volume><issue>4</issue><spage>881</spage><epage>884</epage><pages>881-884</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>1
The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar‐Kyoto (WKY) and Wistar (NWR) rats was supplemented with either 2% calcium lactate in the drinking water or 12.5 μg vitamin D3 100 g−1 body weight daily by gavage, for 14 days.
2
The blood pressure of the SHR treated with either calcium or vitamin D decreased to the same levels as that of WKY and NWR.
3
The response to bradykinin of the SHR isolated duodenum, which is predominantly contractile, upon treatment with vitamin D (but not with calcium), became predominantly relaxant, approaching the normal behaviour of the WKY and NWR duodenum.
4
The relaxant responses of the SHR and WKY duodenum to potassium were smaller than those of NWR, but treatment with vitamin D increased the response in all three rat strains.
5
It is concluded that, besides sharing the hypotensive effect of calcium, vitamin D treatment of SHR has an effect on the duodenum smooth muscle which might be due to calmodulin‐dependent activation of calcium‐dependent potassium channels.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1324053</pmid><doi>10.1111/j.1476-5381.1992.tb09072.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Blood Pressure - drug effects Bradykinin Bradykinin - pharmacology Cholecalciferol - pharmacology duodenum Duodenum - drug effects Duodenum - physiology Female Hypertension - drug therapy Hypertension - physiopathology In Vitro Techniques intestinal smooth muscle Muscle Relaxation - drug effects Potassium - pharmacology Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WKY spontaneously hypertensive rats vitamin D |
| title | Effect of treatment with vitamin D3 on the responses of the duodenum of spontaneously hypertensive rats to bradykinin and to potassium |
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