Cytoprotection by iloprost against paracetamol‐induced toxicity in hamster isolated hepatocytes

1 The ability of iloprost (ZK36374) to protect hamster isolated hepatocytes from the toxic effects of paracetamol and its reactive metabolite N‐acetyl‐p‐benzoquinoneimine (NABQI) was investigated. The cytoprotection provided by iloprost was compared with that of N‐acetyl‐l‐cysteine. 2 Treatment of h...

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Veröffentlicht in:	British journal of pharmacology 1992-02, Vol.105 (2), p.417-423
Hauptverfasser:	Nasseri‐Sina, P., Fawthrop, D.J., Wilson, J., Boobis, A.R., Davies, D.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - antagonists & inhibitors Acetaminophen - toxicity Acetylcysteine - pharmacology Animals Benzoquinones - toxicity Biological and medical sciences Cell Survival - drug effects Cricetinae Cytoprotection Drug toxicity and drugs side effects treatment Glutathione - metabolism hepatocytes iloprost Iloprost - pharmacology Imines - toxicity In Vitro Techniques L-Lactate Dehydrogenase - metabolism Liver - cytology Liver - drug effects Male Medical sciences Mesocricetus paracetamol Pharmacology. Drug treatments Prostaglandin Antagonists - pharmacology prostaglandins Prostaglandins - biosynthesis toxicity Toxicity: digestive system
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