The presence of five cyclic nucleotide phosphodiesterase isoenzyme activities in bovine tracheal smooth muscle and the functional effects of selective inhibitors

1 The profile of cyclic nucleotide phosphodiesterase (PDE) isoenzymes and the relaxant effects of isoenzyme selective inhibitors were examined in bovine tracheal smooth muscle. The compounds examined were the non‐selective inhibitor 3‐isobutyl‐1‐methylxanthine (IBMX), zaprinast (PDE V selective), mi...

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Veröffentlicht in:	British journal of pharmacology 1991-10, Vol.104 (2), p.471-477
Hauptverfasser:	Shahid, Mohammed, Amsterdam, Ronald G.M., Boer, Jacob, Berge, Ronald E., Nicholson, C David, Zaagsma, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	2',3'-Cyclic-Nucleotide Phosphodiesterases - antagonists & inhibitors 2',3'-Cyclic-Nucleotide Phosphodiesterases - isolation & purification 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism Air breathing Animals Biological and medical sciences bovine tracheal smooth muscle relaxation Cattle Chromatography, Affinity Chromatography, Ion Exchange Cyclic nucleotide phosphodiesterase isoenzymes Fundamental and applied biological sciences. Psychology IBMX In Vitro Techniques Isoenzymes - antagonists & inhibitors Isoenzymes - isolation & purification Isoenzymes - metabolism Kinetics milrinone Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - enzymology Org 30029 Org 9935 Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics rolipram Trachea - drug effects Trachea - enzymology Vertebrates: respiratory system zaprinast
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