Carotid vascular effects of ergotamine and dihydroergotamine in the pig: no exclusive mediation via 5‐HT1‐like receptors

1 Though it is well known that the antimigraine drugs ergotamine and dihydroergotamine reduce carotid arteriovenous anastomotic shunting, it is uncertain whether a 5‐HT1‐like receptor is responsible for this effect. Using a high dose of methiothepin (3 mg kg−1), which completely blocks the carotid v...

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Veröffentlicht in:	British journal of pharmacology 1991-09, Vol.104 (1), p.183-189
Hauptverfasser:	Boer, Marinus O., Heiligers, Jan P.C., Saxena, Pramod R.
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐hydroxytryptamine receptors Animals arteriovenous anastomoses Arteriovenous Anastomosis - drug effects Arteriovenous Anastomosis - metabolism Biological and medical sciences Brain Chemistry - drug effects Cardiovascular system Carotid Arteries - drug effects carotid blood flow Coronary Circulation - drug effects cranial arteriovenous shunting in the pig dihydroergotamine Dihydroergotamine - pharmacology Dose-Response Relationship, Drug ergot alkaloids ergotamine Ergotamine - pharmacology Hemodynamics - drug effects Indoles - antagonists & inhibitors Indoles - pharmacology Medical sciences Methiothepin - pharmacology migraine Muscle, Smooth, Vascular - drug effects Oxygen Consumption - drug effects Pharmacology. Drug treatments Receptors, Serotonin - drug effects Sulfonamides - antagonists & inhibitors Sulfonamides - pharmacology Sumatriptan Swine Vasoconstrictor Agents - pharmacology Vasodilator agents. Cerebral vasodilators α‐adrenoceptors
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