The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve‐evoked relaxation of human cavernosal smooth muscle

1 The inhibitory transmission in isolated preparations of cavernosal smooth muscle from human penis has been studied. 2 Electrical field stimulation (EFS; 2–64 pulses/train, 0.8 ms pulse duration, 10 Hz) evoked relaxation of preparations treated with guanethidine (50 μm). The EFS‐evoked relaxations...

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Veröffentlicht in:	British journal of pharmacology 1991-11, Vol.104 (3), p.755-759
Hauptverfasser:	Pickard, R.S., Powell, P.H., Zar, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - analogs & derivatives Arginine - pharmacology Autonomic Nervous System - drug effects Biological and medical sciences Cyclic GMP - antagonists & inhibitors Cyclic GMP - biosynthesis Electric Stimulation Fundamental and applied biological sciences. Psychology Guanethidine - pharmacology Humans In Vitro Techniques Male Mammalian male genital system methylene blue Methylene Blue - pharmacology Morphology. Physiology Muscle Relaxation - physiology Muscle, Smooth - innervation Muscle, Smooth - physiology nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Nitroarginine non‐adrenergic non‐cholinergic transmission penile erection Penis Penis - drug effects Penis - innervation Synaptic Transmission - drug effects Vertebrates: reproduction
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