Degradation of acetylcholine in human airways: role of butyrylcholinesterase

1 Neostigmine and BW284C51 induced concentration‐dependent contractions in human isolated bronchial preparations whereas tetraisopropylpyrophosphoramide (iso‐OMPA) was inactive on airway resting tone. 2 Neostigmine (0.1 μm) or iso‐OMPA (100 μm) increased acetylcholine sensitivity in human isolated b...

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Veröffentlicht in:	British journal of pharmacology 1993-04, Vol.108 (4), p.914-919
Hauptverfasser:	Norel, X., Angrisani, M., Labat, C., Gorenne, I., Dulmet, E., Rossi, F., Brink, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - metabolism acetylcholinesterase Acetylcholinesterase - metabolism Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide - pharmacology Biological and medical sciences Bronchi - enzymology Bronchi - metabolism butyrylcholine butyrylcholinesterase Butyrylcholinesterase - metabolism Cardiorespiratory control. Arterial mecano- and chemoreceptor Choline - metabolism Cholinesterase Inhibitors - pharmacology Cholinesterase Reactivators - pharmacology Female Fundamental and applied biological sciences. Psychology Human bronchus Humans In Vitro Techniques Male Middle Aged Muscle Contraction - drug effects Muscle, Smooth - drug effects neostigmine Neostigmine - pharmacology Respiratory System - enzymology Tetraisopropylpyrophosphamide - pharmacology tetraisopropylpyrophosphoramide Vertebrates: respiratory system
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