Nitric oxide‐mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock

1 The role of an enhanced formation of nitric oxide (NO) and the relative importance of the constitutive and inducible NO synthase (NOS) for the development of immediate (within 60 min) and delayed (at 180 min) vascular hyporeactivity to noradrenaline was investigated in a model of circulatory shock...

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Veröffentlicht in:	British journal of pharmacology 1993-03, Vol.108 (3), p.786-792
Hauptverfasser:	Szabó, Csaba, Mitchell, Jane A., Thiemermann, Christoph, Vane, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - biosynthesis Anesthesia Animals Bacteriology Biological and medical sciences Blood Pressure - drug effects catecholamines circulatory shock Dexamethasone - pharmacology Enzyme Induction - drug effects Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hemodynamics - drug effects hypotension in vivo nitric oxide synthase Lipopolysaccharide Lipopolysaccharides Male Microbiology Nitric Oxide - pharmacology Nitric Oxide Synthase Norepinephrine - pharmacology Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains rat Rats Rats, Wistar Shock, Septic - enzymology Shock, Septic - physiopathology
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