5‐Hydroxytryptamine (5‐HT) mediates potent relaxation in the sheep isolated pulmonary vein via activation of 5‐HT4 receptors

1 We investigated the potent 5‐hydroxytryptamine (5‐HT)‐mediated vasorelaxation of the sheep pulmonary vein. Here we present evidence that this response is due to activation of 5‐HT4 receptors. 2 5‐HT (1–1000 nm) caused concentration‐dependent, maintained relaxations (pEC50 = 8.4 ± 0.1) of isolated...

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Veröffentlicht in:	British journal of pharmacology 1992-10, Vol.107 (2), p.591-596
Hauptverfasser:	Cocks, T.M., Arnold, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT4 receptors 5‐Hydroxytryptamine (5‐HT) Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Blood vessels and receptors Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Female Fundamental and applied biological sciences. Psychology Male Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Nitroarginine Pulmonary Veins - drug effects Pulmonary Veins - physiology Receptors, Serotonin - drug effects Receptors, Serotonin - physiology Serotonin - pharmacology Serotonin Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Sheep sheep pulmonary vein vasorelaxation Vertebrates: cardiovascular system
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