Effects of bradykinin receptor antagonists on antigen‐induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea‐pigs

1 We examined effects of bradykinin (BK) receptor antagonists on airway hyperresponsiveness and eosinophilia in sensitized guinea‐pigs that had been administered single, as well as repeated (chronic) challenges with inhaled ovalbumin. In addition, the effects of BK antagonists on antigen‐induced res...

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Veröffentlicht in:	British journal of pharmacology 1992-11, Vol.107 (3), p.653-659
Hauptverfasser:	Farmer, Stephen G., Wilkins, Deidre E., Meeker, Sonya A., Seeds, Esther A.M., Page, Clive P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology airway allergen challenge Animals antagonist asthma B1 receptor B2 receptor Biological and medical sciences Bradykinin Bradykinin - analogs & derivatives Bradykinin - antagonists & inhibitors Bradykinin - pharmacology Bronchial Hyperreactivity - pathology Dose-Response Relationship, Drug eosinophil Female Guinea Pigs Histamine and antagonists. Allergy Humans hyperresponsiveness Infant, Newborn Male Medical sciences Ovalbumin - immunology Pharmacology. Drug treatments Pulmonary Eosinophilia - chemically induced Pulmonary Eosinophilia - drug therapy Pulmonary Eosinophilia - pathology Receptors, Bradykinin Receptors, Neurotransmitter - antagonists & inhibitors respiratory distress Respiratory Distress Syndrome, Newborn - chemically induced Respiratory Distress Syndrome, Newborn - drug therapy Respiratory Distress Syndrome, Newborn - pathology
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