Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse

ABSTRACT CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of age- and post-mortem interval-matched male cocaine abusers and controls. The presence of cocaine and related metabolites was confirmed...

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Veröffentlicht in:	The hematology journal : the official journal of the European Haematology Association 2003-01, Vol.3 (1), p.27-40
Hauptverfasser:	Lehrmann, E, Oyler, J, Vawter, M P, Hyde, T M, Kolachana, B, Kleinman, J E, Huestis, M A, Becker, K G, Freed, W J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine Cluster Analysis Cocaine abuse Cocaine-Related Disorders - genetics Complications and side effects Crack Cocaine - adverse effects DNA microarrays Gene Expression Gene Expression Profiling - methods Gene Expression Profiling - statistics & numerical data Genetic aspects Genotype Human Genetics Humans Male Middle Aged Oligonucleotide Array Sequence Analysis - methods Oligonucleotide Array Sequence Analysis - statistics & numerical data Oncology original-article Pharmacotherapy Polymerase Chain Reaction - methods Prefrontal Cortex - physiology Psychopharmacology Transcription, Genetic - drug effects Transcriptional Activation - drug effects
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