The effects of calcitonin gene‐related peptide on formation of intra‐articular oedema by inflammatory mediators

1 The temporal and quantitative effects of inflammatory mediators on plasma extravasation in the rat knee were investigated by use of a perfusion technique. 2 Intra‐articular perfusion of substance P (SP), bradykinin or histamine over a 5 min test period produced rapid‐onset and prolonged plasma ext...

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Veröffentlicht in:	British journal of pharmacology 1992-09, Vol.107 (1), p.116-119
Hauptverfasser:	Cruwys, S.C., Kidd, B.L., Mapp, P.I., Walsh, D.A., Blake, D.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences bradykinin Bradykinin - pharmacology Calcitonin Gene-Related Peptide - pharmacology calcitonin gene‐related peptide (CGRP) Capillary Permeability - drug effects Dose-Response Relationship, Drug Edema - chemically induced Fundamental and applied biological sciences. Psychology Histamine - pharmacology Inflammation Joint Diseases - chemically induced joint inflammation Male Molecular and cellular biology neurogenic inflammation neuropeptides Plasma extravasation Rats Rats, Wistar substance P Substance P - pharmacology
Online-Zugang:	Volltext
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