Multiple actions of glaucine on cyclic nucleotide phosphodiesterases, alpha 1-adrenoceptor and benzothiazepine binding site at the calcium channel

1. In the present study, the properties of glaucine (an aporphine structurally related to papaverine) were compared with those of papaverine, diltiazem, nifedipine and prazosin. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determina...

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Veröffentlicht in:	British journal of pharmacology 1992-06, Vol.106 (2), p.387-394
Hauptverfasser:	Ivorra, M D, Lugnier, C, Schott, C, Catret, M, Noguera, M A, Anselmi, E, D'Ocon, P
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - metabolism Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aporphines - pharmacology Binding, Competitive - drug effects Calcium Channels - drug effects Calcium Channels - metabolism Cattle In Vitro Techniques Male Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Norepinephrine - metabolism Phosphodiesterase Inhibitors - pharmacology Prazosin - metabolism Radioligand Assay Rats Rats, Wistar Receptors, Adrenergic, alpha - metabolism
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