A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis. Immunization of B10.PL mice with the Ac1-9 peptide, the immunodominant determinant of myelin basic protein (MBP), produced a single episode of EAE followed by recovery and resistance to reinduction of disease....

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Veröffentlicht in:	The Journal of clinical investigation 2007-08, Vol.117 (8), p.2176-2185
Hauptverfasser:	Menezes, Juscilene S, van den Elzen, Peter, Thornes, Jordan, Huffman, Donald, Droin, Nathalie M, Maverakis, Emanual, Sercarz, Eli E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Care and treatment Complementarity Determining Regions - genetics Complementarity Determining Regions - immunology Disease Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Hypotheses Lymphatic system Lymphocytes Mice Multiple sclerosis Multiple Sclerosis - chemically induced Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - pathology Myelin Basic Protein - genetics Myelin Basic Protein - immunology Myelin Basic Protein - toxicity Organ Specificity - genetics Organ Specificity - immunology Peptide Fragments - genetics Peptide Fragments - immunology Peptide Fragments - toxicity Peptides Proteins Recovery of Function - genetics Recovery of Function - immunology Risk factors Spinal cord Spleen T cells Th1 Cells - immunology Th1 Cells - pathology Th2 Cells - immunology Th2 Cells - pathology Vaccines
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