The dual function of the splenic marginal zone: essential for initiation of anti‐TI‐2 responses but also vital in the general first‐line defense against blood‐borne antigens

Summary The splenic marginal zone (S‐MZ) is especially well equipped for rapid humoral responses and is unique in its ability to initiate an immune response to encapsulated bacteria (T‐cell independent type 2 (TI‐2) antigens). Because of the rapid spreading through the blood, infections with blood‐b...

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Veröffentlicht in:	Clinical and experimental immunology 2002-10, Vol.130 (1), p.4-11
Hauptverfasser:	ZANDVOORT, A., TIMENS, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of the immune response. Humoral and cellular immunity Animals Antigen-Antibody Complex - immunology Antigens, CD - immunology Antigens, CD19 - immunology Antigens, Differentiation - immunology Antigens, T-Independent - immunology B cells B-Lymphocyte Subsets - immunology Biological and medical sciences Blood-Borne Pathogens Complement C3d - immunology Disease Susceptibility Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunoglobulin Class Switching Immunoglobulin M - biosynthesis Immunologic Memory - immunology Infant Lymphocyte Activation Macromolecular Substances Membrane Proteins - immunology memory Mice Mice, Mutant Strains Mice, Nude Organs and cells involved in the immune response pneumococcal polysaccharides Receptors, Complement 3d - immunology Review Spleen - blood supply Spleen - immunology Spleen - microbiology Spleen - ultrastructure Splenectomy - adverse effects splenic marginal zone Tetraspanin 28 T‐cell independent type 2 antigens
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