Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1‐dominated cytokine response

SUMMARY Repeated challenge with antigen is involved in the pathogenesis of a variety of pulmonary diseases. Patients with cystic fibrosis (CF) experience recurrent pulmonary colonization with Pseudomonas aeruginosa before establishment of chronic lung infection. To mimic recurrent lung infections in...

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Veröffentlicht in:	Clinical and experimental immunology 2002-02, Vol.127 (2), p.206-213
Hauptverfasser:	MOSER, C., JENSEN, P. O., KOBAYASHI, O., HOUGEN, H. P., SONG, Z., RYGAARD, J., KHARAZMI, A., H?BY, N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar Alginates Animal Studies Animals Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - blood Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Bronchoalveolar Lavage Fluid CD4 Lymphocyte Count Chronic Disease cytokines Cytokines - biosynthesis Female Glucuronic Acid Hexuronic Acids Human bacterial diseases Immunoglobulin G - biosynthesis Immunoglobulin G - blood Infectious diseases infectious immunity‐bacteria Interferon-gamma - biosynthesis Interleukin-12 - biosynthesis Interleukin-4 - biosynthesis lung Lymphocyte Function-Associated Antigen-1 - biosynthesis Medical sciences Mice Mice, Inbred BALB C Models, Animal Pneumonia, Bacterial - immunology Pseudomonas aeruginosa Pseudomonas Infections - immunology Recurrence rodent Th1 Cells - immunology Th1 Cells - metabolism Th1/Th2
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