Influence of age and HLA type on interferon‐gamma (IFN‐γ) responses to a naturally occurring polymorphic epitope of Plasmodium falciparum liver stage antigen‐1 (LSA‐1)

Antigenic polymorphism and HLA restriction may limit the immunogenicity of a subunit vaccine against liver‐stage Plasmodium falciparum. We examined 59 clinical isolates and five laboratory clones of P. falciparum for polymorphism in the N‐ and C‐terminal regions of LSA‐1, evaluated binding of the co...

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Veröffentlicht in:	Clinical and experimental immunology 2000-10, Vol.122 (1), p.94-100
Hauptverfasser:	Bucci, K., Kastens, W., Hollingdale, M. R., Shankar, A., Alpers, M. P., King, C. L., Kazura, J. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aging - immunology Alleles Animals Antigenic Variation - genetics Antigenic Variation - immunology Antigens, Protozoan - genetics Antigens, Protozoan - immunology Biological and medical sciences Child Child, Preschool cytokine Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology g-Interferon histocompatibility antigen HLA Histocompatibility Testing HLA HLA-A Antigens - genetics HLA-A Antigens - immunology HLA-A11 Antigen HLA-A2 Antigen - immunology HLA-B Antigens - genetics HLA-B Antigens - immunology Human protozoal diseases Humans Immunity to Infection Infectious diseases Interferon-gamma - biosynthesis Interferon-gamma - immunology LSA-1 antigen LSA‐1 Malaria Malaria, Falciparum - epidemiology Malaria, Falciparum - immunology Malaria, Falciparum - physiopathology Medical sciences Middle Aged Papua New Guinea - epidemiology Parasitic diseases Peptides - immunology Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - immunology polymorphism Protozoal diseases Tropical medicine
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