Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti‐PR3 autoantibodies

Anti‐neutrophil cytoplasmic antibodies directed against PR3 (PR3‐ANCA) in patients with Wegener's granulomatosis are supposedly involved in the pathophysiology of this disease as different functional characteristics of the autoantibodies correlate with disease activity. However, little is known...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical and experimental immunology 1999-12, Vol.118 (3), p.487-496
Hauptverfasser:	VAN DER GELD, Y. M, LIMBURG, P. C, KALLENBERG, C. G. M
Format:	Artikel
Sprache:	eng
Schlagworte:	ANCA Antibodies, Antineutrophil Cytoplasmic - metabolism Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - metabolism Antibody Specificity - immunology Autoantibodies - metabolism Autoantigens - immunology Binding, Competitive - immunology Biological and medical sciences Biosensing Techniques biosensor Enzyme-Linked Immunosorbent Assay Epitope Mapping Epitopes - metabolism Flow Cytometry Fluorescent Antibody Technique, Indirect Granulomatosis with Polyangiitis - immunology Humans Immunoblotting Medical sciences Myeloblastin Original proteinase 3 Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Serine Endopeptidases - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!