Contribution of serotype‐specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae
The contribution of serotype‐specific IgG concentration, subclasses, and avidity to opsonophagocytic activity (OPA) against Streptococcus pneumoniae (Pnc) was evaluated in sera of adults and infants immunized with different pneumococcal vaccines. Antibody concentrations and avidities were measured b...
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| Veröffentlicht in: | Clinical and experimental immunology 1999-12, Vol.118 (3), p.402-407 |
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| creator | ANTTILA, M VOUTILAINEN, M JÄNTTI, V ESKOLA, J KÄYHTY, H |
| description | The contribution of serotype‐specific IgG concentration, subclasses, and avidity to opsonophagocytic activity (OPA) against Streptococcus pneumoniae (Pnc) was evaluated in sera of adults and infants immunized with different pneumococcal vaccines. Antibody concentrations and avidities were measured by enzymeimmunoassay (EIA) and OPAs by killing assay of Pnc. The most important factor contributing positively to OPA was the specific IgG level. In infants, a tendency to negative correlation was found between the concentration needed for killing of bacteria and avidity, suggesting that less antibodies of high rather than low avidity were required for killing. No such correlation was seen in adults. However, in adults the avidity was high already before vaccination and the variation was narrow. Thus, avidity was probably not a limiting factor influencing OPA. The effect of IgG2/IgG1 ratio on OPA was mostly negative but insignificant. |
| doi_str_mv | 10.1046/j.1365-2249.1999.01077.x |
| format | Article |
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Antibody concentrations and avidities were measured by enzymeimmunoassay (EIA) and OPAs by killing assay of Pnc. The most important factor contributing positively to OPA was the specific IgG level. In infants, a tendency to negative correlation was found between the concentration needed for killing of bacteria and avidity, suggesting that less antibodies of high rather than low avidity were required for killing. No such correlation was seen in adults. However, in adults the avidity was high already before vaccination and the variation was narrow. Thus, avidity was probably not a limiting factor influencing OPA. The effect of IgG2/IgG1 ratio on OPA was mostly negative but insignificant.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1046/j.1365-2249.1999.01077.x</identifier><identifier>PMID: 10594558</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Adult ; Age Factors ; Antibodies, Bacterial - blood ; Antibodies, Bacterial - classification ; Antibodies, Bacterial - immunology ; Antibody Specificity - immunology ; Applied microbiology ; Bacterial Capsules - immunology ; Bacterial Vaccines - immunology ; Biological and medical sciences ; Biological Assay ; conjugate vaccines ; Dose-Response Relationship, Immunologic ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunoenzyme Techniques ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Immunoglobulin G - immunology ; Infant ; Microbiology ; Opsonin Proteins - immunology ; opsonophagocytic activity ; Original ; Phagocytosis - immunology ; Serotyping ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Streptococcuspneumoniae ; Time Factors ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Clinical and experimental immunology, 1999-12, Vol.118 (3), p.402-407</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Dec 1999</rights><rights>1999 Blackwell Science Inc 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5577-3690e020943010cafdc5060fd0a1840de8f64e3dc65d44ec6102ef96f7f3f76b3</citedby><cites>FETCH-LOGICAL-c5577-3690e020943010cafdc5060fd0a1840de8f64e3dc65d44ec6102ef96f7f3f76b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905437/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905437/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1207491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10594558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANTTILA, M</creatorcontrib><creatorcontrib>VOUTILAINEN, M</creatorcontrib><creatorcontrib>JÄNTTI, V</creatorcontrib><creatorcontrib>ESKOLA, J</creatorcontrib><creatorcontrib>KÄYHTY, H</creatorcontrib><title>Contribution of serotype‐specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>The contribution of serotype‐specific IgG concentration, subclasses, and avidity to opsonophagocytic activity (OPA) against Streptococcus pneumoniae (Pnc) was evaluated in sera of adults and infants immunized with different pneumococcal vaccines. Antibody concentrations and avidities were measured by enzymeimmunoassay (EIA) and OPAs by killing assay of Pnc. The most important factor contributing positively to OPA was the specific IgG level. In infants, a tendency to negative correlation was found between the concentration needed for killing of bacteria and avidity, suggesting that less antibodies of high rather than low avidity were required for killing. No such correlation was seen in adults. However, in adults the avidity was high already before vaccination and the variation was narrow. Thus, avidity was probably not a limiting factor influencing OPA. The effect of IgG2/IgG1 ratio on OPA was mostly negative but insignificant.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibodies, Bacterial - classification</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antibody Specificity - immunology</subject><subject>Applied microbiology</subject><subject>Bacterial Capsules - immunology</subject><subject>Bacterial Vaccines - immunology</subject><subject>Biological and medical sciences</subject><subject>Biological Assay</subject><subject>conjugate vaccines</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin G - immunology</subject><subject>Infant</subject><subject>Microbiology</subject><subject>Opsonin Proteins - immunology</subject><subject>opsonophagocytic activity</subject><subject>Original</subject><subject>Phagocytosis - immunology</subject><subject>Serotyping</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Streptococcuspneumoniae</subject><subject>Time Factors</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks9uEzEQxlcIRNPCKyALIU5NsNd_dn0ACUWlRKrEAThbjnecOtrYy9obujcegVfg1XgSvE1UChc42eP5zTee0VcUiOAFwUy82i4IFXxelkwuiJRygQmuqsXNg2J2l3hYzDDGci5zxUlxGuM2h0KI8nFxQjCXjPN6VvxYBp96tx6SCx4FiyL0IY0d_Pz2PXZgnHUGrTaXyARvIKN6As9vn-KwNq2OESLSvkE9tDm5hxwktw7NiPTeNS6NKAUUuhh86K71JpgxZU1tMjsl9UY7HxP6mHroUjDBmCGizsOwC95peFI8srqN8PR4nhWf3118Wr6fX324XC3fXs0N51U1p0JiwCWWjOZlGG0bw7HAtsGa1Aw3UFvBgDZG8IYxMILgEqwUtrLUVmJNz4o3B91uWO-gOQzbqq53O92PKmin_sx4d602Ya-IxJzRKgu8PAr04csAMamdiwbaVnsIQ1RCUk5JTf8JkorRuqp5Bp__BW7D0Pu8hdxU1JzVbILqA2T6EGMP9u7LBKvJLWqrJlOoyRRqcou6dYu6yaXP7o98r_Bgjwy8OAI6Gt3aXnvj4m-uxBWTJGOvD9hX18L43_3V8mI13egv3ufhTw</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>ANTTILA, M</creator><creator>VOUTILAINEN, M</creator><creator>JÄNTTI, V</creator><creator>ESKOLA, J</creator><creator>KÄYHTY, H</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Oxford University Press</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199912</creationdate><title>Contribution of serotype‐specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae</title><author>ANTTILA, M ; VOUTILAINEN, M ; JÄNTTI, V ; ESKOLA, J ; KÄYHTY, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5577-3690e020943010cafdc5060fd0a1840de8f64e3dc65d44ec6102ef96f7f3f76b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibodies, Bacterial - classification</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Antibody Specificity - immunology</topic><topic>Applied microbiology</topic><topic>Bacterial Capsules - immunology</topic><topic>Bacterial Vaccines - immunology</topic><topic>Biological and medical sciences</topic><topic>Biological Assay</topic><topic>conjugate vaccines</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin G - immunology</topic><topic>Infant</topic><topic>Microbiology</topic><topic>Opsonin Proteins - immunology</topic><topic>opsonophagocytic activity</topic><topic>Original</topic><topic>Phagocytosis - immunology</topic><topic>Serotyping</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Streptococcuspneumoniae</topic><topic>Time Factors</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANTTILA, M</creatorcontrib><creatorcontrib>VOUTILAINEN, M</creatorcontrib><creatorcontrib>JÄNTTI, V</creatorcontrib><creatorcontrib>ESKOLA, J</creatorcontrib><creatorcontrib>KÄYHTY, H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ANTTILA, M</au><au>VOUTILAINEN, M</au><au>JÄNTTI, V</au><au>ESKOLA, J</au><au>KÄYHTY, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contribution of serotype‐specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1999-12</date><risdate>1999</risdate><volume>118</volume><issue>3</issue><spage>402</spage><epage>407</epage><pages>402-407</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>The contribution of serotype‐specific IgG concentration, subclasses, and avidity to opsonophagocytic activity (OPA) against Streptococcus pneumoniae (Pnc) was evaluated in sera of adults and infants immunized with different pneumococcal vaccines. Antibody concentrations and avidities were measured by enzymeimmunoassay (EIA) and OPAs by killing assay of Pnc. The most important factor contributing positively to OPA was the specific IgG level. In infants, a tendency to negative correlation was found between the concentration needed for killing of bacteria and avidity, suggesting that less antibodies of high rather than low avidity were required for killing. No such correlation was seen in adults. However, in adults the avidity was high already before vaccination and the variation was narrow. Thus, avidity was probably not a limiting factor influencing OPA. The effect of IgG2/IgG1 ratio on OPA was mostly negative but insignificant.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>10594558</pmid><doi>10.1046/j.1365-2249.1999.01077.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and experimental immunology, 1999-12, Vol.118 (3), p.402-407 |
| issn | 0009-9104 1365-2249 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Age Factors Antibodies, Bacterial - blood Antibodies, Bacterial - classification Antibodies, Bacterial - immunology Antibody Specificity - immunology Applied microbiology Bacterial Capsules - immunology Bacterial Vaccines - immunology Biological and medical sciences Biological Assay conjugate vaccines Dose-Response Relationship, Immunologic Fundamental and applied biological sciences. Psychology Humans Immunoenzyme Techniques Immunoglobulin G - blood Immunoglobulin G - classification Immunoglobulin G - immunology Infant Microbiology Opsonin Proteins - immunology opsonophagocytic activity Original Phagocytosis - immunology Serotyping Streptococcus pneumoniae Streptococcus pneumoniae - immunology Streptococcuspneumoniae Time Factors Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Contribution of serotype‐specific IgG concentration, IgG subclasses and relative antibody avidity to opsonophagocytic activity against Streptococcus pneumoniae |
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