Endogenous opioids modulate allograft rejection time in mice: possible relation with Th1/Th2 cytokines

The continuous infusion of the opioid peptide β‐endorphin prolongs skin allograft survival in mice, while the opiate receptor antagonist naloxone, administered together with the opioid at the time of transplantation, abolishes the effect of the opioid. Consistently, naloxone, when given alone at the...

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Veröffentlicht in:	Clinical and experimental immunology 1998-09, Vol.113 (3), p.465-469
Hauptverfasser:	SACERDOTE, P, DI SAN SECONDO, V. E. M. R, SIRCHIA, G, MANFREDI, B, PANERAI, A. E
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV allograft Animals beta-Endorphin - analysis beta-Endorphin - physiology Biological and medical sciences cytokines Cytokines - analysis Cytokines - physiology Experimental and animal immunopathology. Animal models Female Graft Rejection Graft Survival Immunopathology Medical sciences Mice Mice, Inbred C57BL naloxone Naloxone - pharmacology opioids Original rejection Skin Transplantation Th1 Cells - physiology Th2 Cells - physiology Transplantation, Homologous β‐endorphin
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