Iodination of human thyroglobulin (Tg) alters its immunoreactivity. I. Iodination alters multiple epitopes of human Tg

Human Tg, the site of synthesis of thyroid hormones, thyroxine (T4) and triiodothyronine (T3), is one of the major autoantigens in autoimmune thyroiditis. The degree of iodination of Tg may have a major impact on its immunological properties by changing its antigenicity with respect to antibody bind...

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Veröffentlicht in:	Clinical and experimental immunology 1998-08, Vol.113 (2), p.297-302
Hauptverfasser:	SABOORI, A. M, ROSE, N. R, BRESLER, H. S, VLADUT-TALOR, M, BUREK, C. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Antibody Specificity Autoantigens - immunology Autoimmune Diseases - immunology autoimmunity Biological and medical sciences Endocrinopathies Epitope Mapping Humans iodine Iodine - immunology Medical sciences monoclonal antibody Non tumoral diseases. Target tissue resistance. Benign neoplasms Original Protein Conformation thyroglobulin Thyroglobulin - analogs & derivatives Thyroglobulin - immunology Thyroid. Thyroid axis (diseases)
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