The effect of cyclosporin A, FK506 and rapamycin on the murine contact sensitivity reaction

We have evaluated the effects of three potent immunosuppressive agents, cyclosporin A (CsA), FK506 and rapamycin, on the murine contact sensitivity (CS) reaction to the hapten trinitrochlorobenzene. Development of CS reaction requires participation of three distinct T cell subsets: αβ+, CD4+ T lymph...

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Veröffentlicht in:	Clinical and experimental immunology 1998-04, Vol.112 (1), p.112-119
Hauptverfasser:	SALERNO, A, BONANNO, C. T, CACCAMO, N, CIGNA, D, DOMINICI, R, FERRO, C, SIRECI, G, DIELI, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences contact sensitivity cyclosporin A Cyclosporine - administration & dosage Dermatitis, Contact - drug therapy Dermatitis, Contact - immunology FK506 Immunomodulators Immunosuppressive Agents - administration & dosage Lymphocyte Activation - drug effects Male Medical sciences Mice Mice, Inbred CBA Original Pharmacology. Drug treatments Picryl Chloride Polyenes - administration & dosage rapamycin Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Antigen, T-Cell, gamma-delta - immunology Sirolimus T cell subsets T-Lymphocyte Subsets - immunology Tacrolimus - administration & dosage
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