Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti‐inflammatory role
The distribution of CD57+ T and CD56+ T cells in patients with RA was examined. In control osteoarthritis patients, these cells exist as a minor population in the peripheral blood. Our data show that in patients with RA, CD57+ T cell levels are elevated in peripheral blood, knee joint fluid, knee sy...
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| Veröffentlicht in: | Clinical and experimental immunology 1998-02, Vol.111 (2), p.345-352 |
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| creator | ARAI, K YAMAMURA, S SEKI, S HANYU, T TAKAHASHI, H. E ABO, T |
| description | The distribution of CD57+ T and CD56+ T cells in patients with RA was examined. In control osteoarthritis patients, these cells exist as a minor population in the peripheral blood. Our data show that in patients with RA, CD57+ T cell levels are elevated in peripheral blood, knee joint fluid, knee synovial membrane and bone marrow (BM), compared with peripheral blood of controls. CD57+ T cells are especially high in knee joint fluid and joint‐adjacent BM, while CD56+ T cells show no such increase. CD57+ T cells contain a major population of CD8+ cells and higher proportions of CD4−8− cells and γδ T cells than do CD57−T cells. CD57+T cells in peripheral blood and joint fluid increase with the duration of disease. Erythrocyte sedimentation rate (ESR) is inversely correlated with the proportion of CD57+T cells in the joint fluid. Although RA frequently occurrs in patients with CD3+57+ cell leukaemia, and some CD57+T cells are likely to be involved in the onset of RA, we suggest that CD57+T cells may rather suppress inflammation of RA, and other cellular components (e. g. granulocytes) may govern the severity of the inflammation of RA. These CD57+ T cells are probably generated extrathymically in the adjacent BM or joint space. |
| doi_str_mv | 10.1046/j.1365-2249.1998.00511.x |
| format | Article |
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E ; ABO, T</creator><creatorcontrib>ARAI, K ; YAMAMURA, S ; SEKI, S ; HANYU, T ; TAKAHASHI, H. E ; ABO, T</creatorcontrib><description>The distribution of CD57+ T and CD56+ T cells in patients with RA was examined. In control osteoarthritis patients, these cells exist as a minor population in the peripheral blood. Our data show that in patients with RA, CD57+ T cell levels are elevated in peripheral blood, knee joint fluid, knee synovial membrane and bone marrow (BM), compared with peripheral blood of controls. CD57+ T cells are especially high in knee joint fluid and joint‐adjacent BM, while CD56+ T cells show no such increase. CD57+ T cells contain a major population of CD8+ cells and higher proportions of CD4−8− cells and γδ T cells than do CD57−T cells. CD57+T cells in peripheral blood and joint fluid increase with the duration of disease. Erythrocyte sedimentation rate (ESR) is inversely correlated with the proportion of CD57+T cells in the joint fluid. Although RA frequently occurrs in patients with CD3+57+ cell leukaemia, and some CD57+T cells are likely to be involved in the onset of RA, we suggest that CD57+T cells may rather suppress inflammation of RA, and other cellular components (e. g. granulocytes) may govern the severity of the inflammation of RA. These CD57+ T cells are probably generated extrathymically in the adjacent BM or joint space.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1046/j.1365-2249.1998.00511.x</identifier><identifier>PMID: 9486402</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; AIDS/HIV ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - pathology ; Biological and medical sciences ; Bone Marrow - immunology ; Bone Marrow - pathology ; CD3+ CD57+ T cells ; CD4-CD8 Ratio ; CD56 Antigen - immunology ; CD57 Antigens - immunology ; Diseases of the osteoarticular system ; erythrocyte sedimentation rate ; Female ; Humans ; joint fluid ; joint‐adjacent bone marrow ; Knee Joint - immunology ; Knee Joint - pathology ; Male ; Medical sciences ; Middle Aged ; Original ; Receptors, Antigen, T-Cell, gamma-delta - immunology ; rheumatoid arthritis ; Synovial Fluid - immunology ; T-Lymphocytes - immunology ; Tumors of striated muscle and skeleton</subject><ispartof>Clinical and experimental immunology, 1998-02, Vol.111 (2), p.345-352</ispartof><rights>Blackwell Science Ltd, Oxford</rights><rights>1998 INIST-CNRS</rights><rights>1998 Blackwell Science Ltd 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4291-708b997810a5133285643592e4f1d074df84ba7437d06d2a36056d5c3e5ab7fb3</citedby><cites>FETCH-LOGICAL-c4291-708b997810a5133285643592e4f1d074df84ba7437d06d2a36056d5c3e5ab7fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904913/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904913/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2126445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9486402$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARAI, K</creatorcontrib><creatorcontrib>YAMAMURA, S</creatorcontrib><creatorcontrib>SEKI, S</creatorcontrib><creatorcontrib>HANYU, T</creatorcontrib><creatorcontrib>TAKAHASHI, H. E</creatorcontrib><creatorcontrib>ABO, T</creatorcontrib><title>Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti‐inflammatory role</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>The distribution of CD57+ T and CD56+ T cells in patients with RA was examined. In control osteoarthritis patients, these cells exist as a minor population in the peripheral blood. Our data show that in patients with RA, CD57+ T cell levels are elevated in peripheral blood, knee joint fluid, knee synovial membrane and bone marrow (BM), compared with peripheral blood of controls. CD57+ T cells are especially high in knee joint fluid and joint‐adjacent BM, while CD56+ T cells show no such increase. CD57+ T cells contain a major population of CD8+ cells and higher proportions of CD4−8− cells and γδ T cells than do CD57−T cells. CD57+T cells in peripheral blood and joint fluid increase with the duration of disease. Erythrocyte sedimentation rate (ESR) is inversely correlated with the proportion of CD57+T cells in the joint fluid. Although RA frequently occurrs in patients with CD3+57+ cell leukaemia, and some CD57+T cells are likely to be involved in the onset of RA, we suggest that CD57+T cells may rather suppress inflammation of RA, and other cellular components (e. g. granulocytes) may govern the severity of the inflammation of RA. These CD57+ T cells are probably generated extrathymically in the adjacent BM or joint space.</description><subject>Adult</subject><subject>Aged</subject><subject>AIDS/HIV</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - immunology</subject><subject>Bone Marrow - pathology</subject><subject>CD3+ CD57+ T cells</subject><subject>CD4-CD8 Ratio</subject><subject>CD56 Antigen - immunology</subject><subject>CD57 Antigens - immunology</subject><subject>Diseases of the osteoarticular system</subject><subject>erythrocyte sedimentation rate</subject><subject>Female</subject><subject>Humans</subject><subject>joint fluid</subject><subject>joint‐adjacent bone marrow</subject><subject>Knee Joint - immunology</subject><subject>Knee Joint - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - immunology</subject><subject>rheumatoid arthritis</subject><subject>Synovial Fluid - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0009-9104</issn><issn>1365-2249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUd2K1DAUDqKs4-gjCLkQUaQ1SZO0ERGWcdWBBUHW63Dapk5qm8wmHXfnzkfwwif0SUydYdA7IZAcvp9zTj6EMCU5JVy-7HNaSJExxlVOlapyQgSl-e0dtDgBd9GCEKIylRT30YMY-1RKKdkZOlO8kpywBfq5dk0wEA32HV69FeULfIUbMwwRW4e_OmNw762bIgbXYmh7aIybcO2dwSOE4G9mYdiY3QiTt4kSpk2wk4342afz53gLk02C-ArbcTvYJpXe4c6H5JfOZH99_2FdN8A468MeBz-Yh-heB0M0j473En1-d3G1-pBdfny_Xp1fZg1nimYlqWqlyooSELQoWCUkL4Rihne0JSVvu4rXUPKibIlsGRSSCNmKpjAC6rKriyV6c_Dd7urRtPNmAQa9DTatttcerP4XcXajv_hvmirCVWq5RE-PBsFf70yc9Gjj_HvgjN9FXaqSMJWmWqLqQGyCjzGY7tSEEj0nqns9B6fn4PScqP6TqL5N0sd_D3kSHiNM-JMjDrGBoQvgGhtPNEaZ5Fwk2usD7cYOZv_f7fXqYp0exW8xpL48</recordid><startdate>199802</startdate><enddate>199802</enddate><creator>ARAI, K</creator><creator>YAMAMURA, S</creator><creator>SEKI, S</creator><creator>HANYU, T</creator><creator>TAKAHASHI, H. E</creator><creator>ABO, T</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199802</creationdate><title>Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti‐inflammatory role</title><author>ARAI, K ; YAMAMURA, S ; SEKI, S ; HANYU, T ; TAKAHASHI, H. E ; ABO, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4291-708b997810a5133285643592e4f1d074df84ba7437d06d2a36056d5c3e5ab7fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AIDS/HIV</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - immunology</topic><topic>Bone Marrow - pathology</topic><topic>CD3+ CD57+ T cells</topic><topic>CD4-CD8 Ratio</topic><topic>CD56 Antigen - immunology</topic><topic>CD57 Antigens - immunology</topic><topic>Diseases of the osteoarticular system</topic><topic>erythrocyte sedimentation rate</topic><topic>Female</topic><topic>Humans</topic><topic>joint fluid</topic><topic>joint‐adjacent bone marrow</topic><topic>Knee Joint - immunology</topic><topic>Knee Joint - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - immunology</topic><topic>rheumatoid arthritis</topic><topic>Synovial Fluid - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARAI, K</creatorcontrib><creatorcontrib>YAMAMURA, S</creatorcontrib><creatorcontrib>SEKI, S</creatorcontrib><creatorcontrib>HANYU, T</creatorcontrib><creatorcontrib>TAKAHASHI, H. E</creatorcontrib><creatorcontrib>ABO, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARAI, K</au><au>YAMAMURA, S</au><au>SEKI, S</au><au>HANYU, T</au><au>TAKAHASHI, H. E</au><au>ABO, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti‐inflammatory role</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1998-02</date><risdate>1998</risdate><volume>111</volume><issue>2</issue><spage>345</spage><epage>352</epage><pages>345-352</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>The distribution of CD57+ T and CD56+ T cells in patients with RA was examined. In control osteoarthritis patients, these cells exist as a minor population in the peripheral blood. Our data show that in patients with RA, CD57+ T cell levels are elevated in peripheral blood, knee joint fluid, knee synovial membrane and bone marrow (BM), compared with peripheral blood of controls. CD57+ T cells are especially high in knee joint fluid and joint‐adjacent BM, while CD56+ T cells show no such increase. CD57+ T cells contain a major population of CD8+ cells and higher proportions of CD4−8− cells and γδ T cells than do CD57−T cells. CD57+T cells in peripheral blood and joint fluid increase with the duration of disease. Erythrocyte sedimentation rate (ESR) is inversely correlated with the proportion of CD57+T cells in the joint fluid. Although RA frequently occurrs in patients with CD3+57+ cell leukaemia, and some CD57+T cells are likely to be involved in the onset of RA, we suggest that CD57+T cells may rather suppress inflammation of RA, and other cellular components (e. g. granulocytes) may govern the severity of the inflammation of RA. These CD57+ T cells are probably generated extrathymically in the adjacent BM or joint space.</abstract><cop>Oxford BSL</cop><pub>Blackwell Publishing Ltd</pub><pmid>9486402</pmid><doi>10.1046/j.1365-2249.1998.00511.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged AIDS/HIV Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Biological and medical sciences Bone Marrow - immunology Bone Marrow - pathology CD3+ CD57+ T cells CD4-CD8 Ratio CD56 Antigen - immunology CD57 Antigens - immunology Diseases of the osteoarticular system erythrocyte sedimentation rate Female Humans joint fluid joint‐adjacent bone marrow Knee Joint - immunology Knee Joint - pathology Male Medical sciences Middle Aged Original Receptors, Antigen, T-Cell, gamma-delta - immunology rheumatoid arthritis Synovial Fluid - immunology T-Lymphocytes - immunology Tumors of striated muscle and skeleton |
| title | Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti‐inflammatory role |
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