Cytomegalovirus (CMV) infection in AIDS patients is associated with a CD3 receptor‐mediated T cell hyporesponsiveness
HIV+ individuals with human CMV (HCMV) reactivation have a CD3 receptor‐mediated T cell hyporesponsiveness when compared with CD4‐matched HIV+ and HCMV−control groups. The impairment of proliferation was not reversed by exogenous IL‐2. A typical increase in NFκB expression was observed following cro...
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| Veröffentlicht in: | Clinical and experimental immunology 1998-03, Vol.111 (3), p.559-563 |
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| creator | ROWBOTTOM, A. W LEPPER, M. W SHARPSTONE, D GAZZARD, B |
| description | HIV+ individuals with human CMV (HCMV) reactivation have a CD3 receptor‐mediated T cell hyporesponsiveness when compared with CD4‐matched HIV+ and HCMV−control groups. The impairment of proliferation was not reversed by exogenous IL‐2. A typical increase in NFκB expression was observed following cross‐linking of the CD3 receptor, but did not lead to increased CD25 cell surface expression or cell proliferation. The HCMV‐induced non‐responsiveness was not observed when cells were stimulated with phorbol esters. Lymphocytes cultured with media collected from cell cultures infected with HCMV showed a dose‐dependent inhibition in the total T cell population even though cells staining dually for CD8/57 increased in number. The altered growth factor requirements of CD8/57+ cells may therefore account for their presence in AIDS and patients following bone marrow transplantation. |
| doi_str_mv | 10.1046/j.1365-2249.1998.00515.x |
| format | Article |
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W ; LEPPER, M. W ; SHARPSTONE, D ; GAZZARD, B</creator><creatorcontrib>ROWBOTTOM, A. W ; LEPPER, M. W ; SHARPSTONE, D ; GAZZARD, B</creatorcontrib><description>HIV+ individuals with human CMV (HCMV) reactivation have a CD3 receptor‐mediated T cell hyporesponsiveness when compared with CD4‐matched HIV+ and HCMV−control groups. The impairment of proliferation was not reversed by exogenous IL‐2. A typical increase in NFκB expression was observed following cross‐linking of the CD3 receptor, but did not lead to increased CD25 cell surface expression or cell proliferation. The HCMV‐induced non‐responsiveness was not observed when cells were stimulated with phorbol esters. Lymphocytes cultured with media collected from cell cultures infected with HCMV showed a dose‐dependent inhibition in the total T cell population even though cells staining dually for CD8/57 increased in number. The altered growth factor requirements of CD8/57+ cells may therefore account for their presence in AIDS and patients following bone marrow transplantation.</description><identifier>ISSN: 0009-9104</identifier><identifier>EISSN: 1365-2249</identifier><identifier>DOI: 10.1046/j.1365-2249.1998.00515.x</identifier><identifier>PMID: 9528899</identifier><identifier>CODEN: CEXIAL</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - virology ; AIDS-Related Opportunistic Infections - blood ; AIDS-Related Opportunistic Infections - immunology ; AIDS-Related Opportunistic Infections - virology ; AIDS/HIV ; Antibodies, Monoclonal - pharmacology ; Biological and medical sciences ; CD3 Complex - immunology ; CD8/57+ lymphocytes ; cytomegalovirus ; Cytomegalovirus Infections - blood ; Cytomegalovirus Infections - immunology ; Cytomegalovirus Infections - virology ; Gene Expression ; HIV ; Human viral diseases ; Humans ; Infectious diseases ; Interleukin-2 - pharmacology ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - immunology ; Lymphocyte Activation - drug effects ; Lymphocyte Activation - physiology ; Medical sciences ; NF-kappa B - biosynthesis ; Original ; T cell activation ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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W</creatorcontrib><creatorcontrib>LEPPER, M. W</creatorcontrib><creatorcontrib>SHARPSTONE, D</creatorcontrib><creatorcontrib>GAZZARD, B</creatorcontrib><title>Cytomegalovirus (CMV) infection in AIDS patients is associated with a CD3 receptor‐mediated T cell hyporesponsiveness</title><title>Clinical and experimental immunology</title><addtitle>Clin Exp Immunol</addtitle><description>HIV+ individuals with human CMV (HCMV) reactivation have a CD3 receptor‐mediated T cell hyporesponsiveness when compared with CD4‐matched HIV+ and HCMV−control groups. The impairment of proliferation was not reversed by exogenous IL‐2. A typical increase in NFκB expression was observed following cross‐linking of the CD3 receptor, but did not lead to increased CD25 cell surface expression or cell proliferation. The HCMV‐induced non‐responsiveness was not observed when cells were stimulated with phorbol esters. Lymphocytes cultured with media collected from cell cultures infected with HCMV showed a dose‐dependent inhibition in the total T cell population even though cells staining dually for CD8/57 increased in number. The altered growth factor requirements of CD8/57+ cells may therefore account for their presence in AIDS and patients following bone marrow transplantation.</description><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>AIDS-Related Opportunistic Infections - blood</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS-Related Opportunistic Infections - virology</subject><subject>AIDS/HIV</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Biological and medical sciences</subject><subject>CD3 Complex - immunology</subject><subject>CD8/57+ lymphocytes</subject><subject>cytomegalovirus</subject><subject>Cytomegalovirus Infections - blood</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Cytomegalovirus Infections - virology</subject><subject>Gene Expression</subject><subject>HIV</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interleukin-2 - pharmacology</subject><subject>Leukocytes, Mononuclear - drug effects</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte Activation - physiology</subject><subject>Medical sciences</subject><subject>NF-kappa B - biosynthesis</subject><subject>Original</subject><subject>T cell activation</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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W</creator><creator>SHARPSTONE, D</creator><creator>GAZZARD, B</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199803</creationdate><title>Cytomegalovirus (CMV) infection in AIDS patients is associated with a CD3 receptor‐mediated T cell hyporesponsiveness</title><author>ROWBOTTOM, A. W ; LEPPER, M. W ; SHARPSTONE, D ; GAZZARD, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5285-1088535428f647517d9dd526338722421260902bba764e2a1147c18ec05d67463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Acquired Immunodeficiency Syndrome - virology</topic><topic>AIDS-Related Opportunistic Infections - blood</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS-Related Opportunistic Infections - virology</topic><topic>AIDS/HIV</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Biological and medical sciences</topic><topic>CD3 Complex - immunology</topic><topic>CD8/57+ lymphocytes</topic><topic>cytomegalovirus</topic><topic>Cytomegalovirus Infections - blood</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Cytomegalovirus Infections - virology</topic><topic>Gene Expression</topic><topic>HIV</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interleukin-2 - pharmacology</topic><topic>Leukocytes, Mononuclear - drug effects</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocyte Activation - physiology</topic><topic>Medical sciences</topic><topic>NF-kappa B - biosynthesis</topic><topic>Original</topic><topic>T cell activation</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ROWBOTTOM, A. W</creatorcontrib><creatorcontrib>LEPPER, M. W</creatorcontrib><creatorcontrib>SHARPSTONE, D</creatorcontrib><creatorcontrib>GAZZARD, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ROWBOTTOM, A. W</au><au>LEPPER, M. W</au><au>SHARPSTONE, D</au><au>GAZZARD, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytomegalovirus (CMV) infection in AIDS patients is associated with a CD3 receptor‐mediated T cell hyporesponsiveness</atitle><jtitle>Clinical and experimental immunology</jtitle><addtitle>Clin Exp Immunol</addtitle><date>1998-03</date><risdate>1998</risdate><volume>111</volume><issue>3</issue><spage>559</spage><epage>563</epage><pages>559-563</pages><issn>0009-9104</issn><eissn>1365-2249</eissn><coden>CEXIAL</coden><abstract>HIV+ individuals with human CMV (HCMV) reactivation have a CD3 receptor‐mediated T cell hyporesponsiveness when compared with CD4‐matched HIV+ and HCMV−control groups. The impairment of proliferation was not reversed by exogenous IL‐2. A typical increase in NFκB expression was observed following cross‐linking of the CD3 receptor, but did not lead to increased CD25 cell surface expression or cell proliferation. The HCMV‐induced non‐responsiveness was not observed when cells were stimulated with phorbol esters. Lymphocytes cultured with media collected from cell cultures infected with HCMV showed a dose‐dependent inhibition in the total T cell population even though cells staining dually for CD8/57 increased in number. The altered growth factor requirements of CD8/57+ cells may therefore account for their presence in AIDS and patients following bone marrow transplantation.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>9528899</pmid><doi>10.1046/j.1365-2249.1998.00515.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical and experimental immunology, 1998-03, Vol.111 (3), p.559-563 |
| issn | 0009-9104 1365-2249 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - virology AIDS-Related Opportunistic Infections - blood AIDS-Related Opportunistic Infections - immunology AIDS-Related Opportunistic Infections - virology AIDS/HIV Antibodies, Monoclonal - pharmacology Biological and medical sciences CD3 Complex - immunology CD8/57+ lymphocytes cytomegalovirus Cytomegalovirus Infections - blood Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology Gene Expression HIV Human viral diseases Humans Infectious diseases Interleukin-2 - pharmacology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - physiology Medical sciences NF-kappa B - biosynthesis Original T cell activation T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Cytomegalovirus (CMV) infection in AIDS patients is associated with a CD3 receptor‐mediated T cell hyporesponsiveness |
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