RP1 Is Required for the Correct Stacking of Outer Segment Discs

Mutations in RP1 are a common cause of dominant retinitis pigmentosa (RP), but the mechanism by which the identified mutations lead to photoreceptor cell death and blindness has not been determined. To investigate the function of the RP1 protein in photoreceptors and gain insight into the mechanism...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2003-10, Vol.44 (10), p.4171-4183
Hauptverfasser:	Liu, Qin, Lyubarsky, Arkady, Skalet, Jason H, Pugh, Edward N., Jr, Pierce, Eric A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Electroretinography Eye Proteins - physiology Gene Expression Gene Targeting Humans Medical sciences Mice Mice, Knockout Mice, Mutant Strains Microscopy, Confocal Ophthalmology Retinitis Pigmentosa - metabolism Retinitis Pigmentosa - pathology Retinopathies Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Rod Cell Outer Segment - physiology Rod Cell Outer Segment - ultrastructure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!