Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study
Among 300 surgically removed pituitary adenomas, 17 tumors containing immunoreactive 1-39 adrenocorticotropin (ACTH) and/or 19-39 ACTH, beta-lipotropin, and alpha-endorphin but unassociated with clinical signs of Cushing's disease have been detected. These neoplasms were divided into basophilic...
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| Veröffentlicht in: | The American journal of pathology 1980-03, Vol.98 (3), p.617-638 |
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| container_title | The American journal of pathology |
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| creator | Horvath, E Kovacs, K Killinger, DW Smyth, HS Platts, ME Singer, W |
| description | Among 300 surgically removed pituitary adenomas, 17 tumors containing immunoreactive 1-39 adrenocorticotropin (ACTH) and/or 19-39 ACTH, beta-lipotropin, and alpha-endorphin but unassociated with clinical signs of Cushing's disease have been detected. These neoplasms were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) and lead-hematoxylin positivity and chromophobic tumors with moderate or no PAS and lead-hematoxylin positivity. The former were densely granulated tumors with a fine structure strikingly similar to that of functioning corticotropic cell adenomas. The latter were sparsely granulated with varying ultrastructural patterns. The marked morphologic diversity suggests that these adenomas, despite their similar immunocytologic characteristics, represent more than one entity. Clinically, the most common finding was a rapidly progressing visual defect. An unusually high incidence of infarction (5 cases) and recurrence (5 cases) was noted, underlining the importance of correct morphologic diagnosis and careful follow-up. |
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These neoplasms were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) and lead-hematoxylin positivity and chromophobic tumors with moderate or no PAS and lead-hematoxylin positivity. The former were densely granulated tumors with a fine structure strikingly similar to that of functioning corticotropic cell adenomas. The latter were sparsely granulated with varying ultrastructural patterns. The marked morphologic diversity suggests that these adenomas, despite their similar immunocytologic characteristics, represent more than one entity. Clinically, the most common finding was a rapidly progressing visual defect. An unusually high incidence of infarction (5 cases) and recurrence (5 cases) was noted, underlining the importance of correct morphologic diagnosis and careful follow-up.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>PMID: 6244736</identifier><language>eng</language><publisher>United States: ASIP</publisher><subject>Adenoma - analysis ; Adenoma - ultrastructure ; Adenoma, Basophil - ultrastructure ; Adenoma, Chromophobe - ultrastructure ; Adrenocorticotropic Hormone - analysis ; Adrenocorticotropic Hormone - immunology ; Adult ; Aged ; beta-Lipotropin - analysis ; Endorphins - analysis ; Female ; Histocytochemistry ; Humans ; Male ; Middle Aged ; Pituitary Gland - analysis ; Pituitary Gland - ultrastructure ; Pituitary Neoplasms - analysis ; Pituitary Neoplasms - ultrastructure</subject><ispartof>The American journal of pathology, 1980-03, Vol.98 (3), p.617-638</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903510/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1903510/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6244736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horvath, E</creatorcontrib><creatorcontrib>Kovacs, K</creatorcontrib><creatorcontrib>Killinger, DW</creatorcontrib><creatorcontrib>Smyth, HS</creatorcontrib><creatorcontrib>Platts, ME</creatorcontrib><creatorcontrib>Singer, W</creatorcontrib><title>Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>Among 300 surgically removed pituitary adenomas, 17 tumors containing immunoreactive 1-39 adrenocorticotropin (ACTH) and/or 19-39 ACTH, beta-lipotropin, and alpha-endorphin but unassociated with clinical signs of Cushing's disease have been detected. These neoplasms were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) and lead-hematoxylin positivity and chromophobic tumors with moderate or no PAS and lead-hematoxylin positivity. The former were densely granulated tumors with a fine structure strikingly similar to that of functioning corticotropic cell adenomas. The latter were sparsely granulated with varying ultrastructural patterns. The marked morphologic diversity suggests that these adenomas, despite their similar immunocytologic characteristics, represent more than one entity. Clinically, the most common finding was a rapidly progressing visual defect. An unusually high incidence of infarction (5 cases) and recurrence (5 cases) was noted, underlining the importance of correct morphologic diagnosis and careful follow-up.</description><subject>Adenoma - analysis</subject><subject>Adenoma - ultrastructure</subject><subject>Adenoma, Basophil - ultrastructure</subject><subject>Adenoma, Chromophobe - ultrastructure</subject><subject>Adrenocorticotropic Hormone - analysis</subject><subject>Adrenocorticotropic Hormone - immunology</subject><subject>Adult</subject><subject>Aged</subject><subject>beta-Lipotropin - analysis</subject><subject>Endorphins - analysis</subject><subject>Female</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pituitary Gland - analysis</subject><subject>Pituitary Gland - ultrastructure</subject><subject>Pituitary Neoplasms - analysis</subject><subject>Pituitary Neoplasms - ultrastructure</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUMtKxDAULaKM4-MThGx0ZSFJ07R1IYj4ggEX6jpck3SaIW1qHsr8vQEH0dXl3nM4j7tXLElN65KSjuwXS4wxLTvG8GFxFMImr7xq8aJYcMpYU_FlEV-M1VNE0vlopIvezUYiUHpyIwTkehQHjYY0woRmE5OJ4LdobWFSVwjQYEJ01q2NvERmHNPk5Pb3kDko2eghRJ9kTB4sCjGp7Ulx0IMN-nQ3j4u3-7vX28dy9fzwdHuzKgfakVgyaNse6l4xrDjwChpCmZSMQqM63GJCqeoa3vGqb2pJJcWSY6XeGcWUtFhXx8X1j-6c3ketZC6aM4jZmzG3EA6M-I9MZhBr9ylIh6ua4CxwsRPw7iPpEMVogtQ219cuBdHUuOactJl49tfp12L354yf_-CDWQ9fxmsRRrA2s4mAzdy1ohKcNNU3beuK9w</recordid><startdate>19800301</startdate><enddate>19800301</enddate><creator>Horvath, E</creator><creator>Kovacs, K</creator><creator>Killinger, DW</creator><creator>Smyth, HS</creator><creator>Platts, ME</creator><creator>Singer, W</creator><general>ASIP</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19800301</creationdate><title>Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study</title><author>Horvath, E ; Kovacs, K ; Killinger, DW ; Smyth, HS ; Platts, ME ; Singer, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h291t-4a88fa5fd40d6a63a7124cc42a7d9080122d976963f75c2c20c60ddb4202180e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Adenoma - analysis</topic><topic>Adenoma - ultrastructure</topic><topic>Adenoma, Basophil - ultrastructure</topic><topic>Adenoma, Chromophobe - ultrastructure</topic><topic>Adrenocorticotropic Hormone - analysis</topic><topic>Adrenocorticotropic Hormone - immunology</topic><topic>Adult</topic><topic>Aged</topic><topic>beta-Lipotropin - analysis</topic><topic>Endorphins - analysis</topic><topic>Female</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pituitary Gland - analysis</topic><topic>Pituitary Gland - ultrastructure</topic><topic>Pituitary Neoplasms - analysis</topic><topic>Pituitary Neoplasms - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horvath, E</creatorcontrib><creatorcontrib>Kovacs, K</creatorcontrib><creatorcontrib>Killinger, DW</creatorcontrib><creatorcontrib>Smyth, HS</creatorcontrib><creatorcontrib>Platts, ME</creatorcontrib><creatorcontrib>Singer, W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horvath, E</au><au>Kovacs, K</au><au>Killinger, DW</au><au>Smyth, HS</au><au>Platts, ME</au><au>Singer, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1980-03-01</date><risdate>1980</risdate><volume>98</volume><issue>3</issue><spage>617</spage><epage>638</epage><pages>617-638</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><abstract>Among 300 surgically removed pituitary adenomas, 17 tumors containing immunoreactive 1-39 adrenocorticotropin (ACTH) and/or 19-39 ACTH, beta-lipotropin, and alpha-endorphin but unassociated with clinical signs of Cushing's disease have been detected. These neoplasms were divided into basophilic adenomas with strong periodic acid-Schiff (PAS) and lead-hematoxylin positivity and chromophobic tumors with moderate or no PAS and lead-hematoxylin positivity. The former were densely granulated tumors with a fine structure strikingly similar to that of functioning corticotropic cell adenomas. The latter were sparsely granulated with varying ultrastructural patterns. The marked morphologic diversity suggests that these adenomas, despite their similar immunocytologic characteristics, represent more than one entity. Clinically, the most common finding was a rapidly progressing visual defect. An unusually high incidence of infarction (5 cases) and recurrence (5 cases) was noted, underlining the importance of correct morphologic diagnosis and careful follow-up.</abstract><cop>United States</cop><pub>ASIP</pub><pmid>6244736</pmid><tpages>22</tpages></addata></record> |
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| subjects | Adenoma - analysis Adenoma - ultrastructure Adenoma, Basophil - ultrastructure Adenoma, Chromophobe - ultrastructure Adrenocorticotropic Hormone - analysis Adrenocorticotropic Hormone - immunology Adult Aged beta-Lipotropin - analysis Endorphins - analysis Female Histocytochemistry Humans Male Middle Aged Pituitary Gland - analysis Pituitary Gland - ultrastructure Pituitary Neoplasms - analysis Pituitary Neoplasms - ultrastructure |
| title | Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study |
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