Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice. A histologic and immunocytochemical analysis

The cellular mechanisms governing the expression of mononuclear cell vasculitis are poorly understood. For determination of the precise sequence of events in the development of vasculitis in autoimmune MRL/lpr mice, histologic sections from 4-20-week-old mice were evaluated with a panel of cytochemi...

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Veröffentlicht in:The American journal of pathology 1987-05, Vol.127 (2), p.229-242
Hauptverfasser: Moyer, CF, Strandberg, JD, Reinisch, CL
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container_title The American journal of pathology
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creator Moyer, CF
Strandberg, JD
Reinisch, CL
description The cellular mechanisms governing the expression of mononuclear cell vasculitis are poorly understood. For determination of the precise sequence of events in the development of vasculitis in autoimmune MRL/lpr mice, histologic sections from 4-20-week-old mice were evaluated with a panel of cytochemical and immunohistochemical stains. The results show that vascular disease in MRL/lpr mice develops as follows: Thy 1+, Ly 1+, L3T4- T cells assemble around predominantly small-to-medium muscular arteries at approximately 8 weeks of age. At 12 weeks of age, an adventitial inflammatory focus forms, composed of large "reactive" mononuclear inflammatory cells adjacent to hypertrophied vascular smooth muscle cells (VSMCs). Blastic Thy 1+, Ly 1+, L3T4- T cells subsequently infiltrate the tunica media, and selective VSMC karyolysis results. Occasional cytotoxic/suppressor T cells, macrophages, and possibly NK cells are noted primarily distal to the infiltration site. The outer zone of the inflammatory infiltrate is composed of mature B cells and occasional B-cell precursors. These findings suggest that cellular constituents of the immune response mediate mononuclear cell vasculitis in MRL/lpr mice.
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Occasional cytotoxic/suppressor T cells, macrophages, and possibly NK cells are noted primarily distal to the infiltration site. The outer zone of the inflammatory infiltrate is composed of mature B cells and occasional B-cell precursors. 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A histologic and immunocytochemical analysis</title><author>Moyer, CF ; Strandberg, JD ; Reinisch, CL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h321t-70ac587ec85de6eea51fba6d41a87a77a7c5515d169fd02ea0acfa79eafa15323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Antigens, Differentiation, T-Lymphocyte</topic><topic>Antigens, Surface - analysis</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - pathology</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Female</topic><topic>Histocompatibility Antigens - analysis</topic><topic>Histocytochemistry</topic><topic>Lymphocytes - pathology</topic><topic>Lymphoproliferative Disorders - pathology</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Neutrophils - pathology</topic><topic>Receptors, Immunologic - analysis</topic><topic>Receptors, Interleukin-2</topic><topic>T-Lymphocytes - immunology</topic><topic>Vascular disorders of the skin</topic><topic>Vasculitis - immunology</topic><topic>Vasculitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moyer, CF</creatorcontrib><creatorcontrib>Strandberg, JD</creatorcontrib><creatorcontrib>Reinisch, CL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moyer, CF</au><au>Strandberg, JD</au><au>Reinisch, CL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice. A histologic and immunocytochemical analysis</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>127</volume><issue>2</issue><spage>229</spage><epage>242</epage><pages>229-242</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><coden>AJPAA4</coden><abstract>The cellular mechanisms governing the expression of mononuclear cell vasculitis are poorly understood. For determination of the precise sequence of events in the development of vasculitis in autoimmune MRL/lpr mice, histologic sections from 4-20-week-old mice were evaluated with a panel of cytochemical and immunohistochemical stains. The results show that vascular disease in MRL/lpr mice develops as follows: Thy 1+, Ly 1+, L3T4- T cells assemble around predominantly small-to-medium muscular arteries at approximately 8 weeks of age. 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subjects Animals
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface - analysis
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Biological and medical sciences
Dermatology
Female
Histocompatibility Antigens - analysis
Histocytochemistry
Lymphocytes - pathology
Lymphoproliferative Disorders - pathology
Macrophages - pathology
Male
Medical sciences
Muscle, Smooth, Vascular - pathology
Neutrophils - pathology
Receptors, Immunologic - analysis
Receptors, Interleukin-2
T-Lymphocytes - immunology
Vascular disorders of the skin
Vasculitis - immunology
Vasculitis - pathology
title Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice. A histologic and immunocytochemical analysis
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