Angiotensin II Type 1 and Type 2 Receptors Play Opposite Roles in Regulating the Barrier Function of Kidney Glomerular Capillary Wall

Although angiotensin II (Ang II) type 1 receptor antagonist ameliorates proteinuria, its pharmacological mechanism and the differential roles of Ang II type 1 receptor (AT1R) and type 2 receptor (AT2R) are not well understood. We analyzed the effect of Ang II type 1 receptor antagonist on proteinuri...

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Veröffentlicht in:	The American journal of pathology 2007-06, Vol.170 (6), p.1841-1853
Hauptverfasser:	Suzuki, Koichi, Han, Gi Dong, Miyauchi, Naoko, Hashimoto, Taeko, Nakatsue, Takeshi, Fujioka, Yumiko, Koike, Hiroko, Shimizu, Fujio, Kawachi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - metabolism Angiotensin II Type 1 Receptor Blockers - metabolism Angiotensin II Type 2 Receptor Blockers Animals Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - toxicity Biological and medical sciences Capillaries - cytology Capillaries - metabolism Female Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Investigative techniques, diagnostic techniques (general aspects) Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphoproteins - genetics Phosphoproteins - metabolism Podocytes - cytology Podocytes - metabolism Proteinuria Rats Receptor, Angiotensin, Type 1 - agonists Receptor, Angiotensin, Type 1 - genetics Receptor, Angiotensin, Type 1 - metabolism Receptor, Angiotensin, Type 2 - agonists Receptor, Angiotensin, Type 2 - genetics Receptor, Angiotensin, Type 2 - metabolism Regular Sialoglycoproteins - genetics Sialoglycoproteins - metabolism Zonula Occludens-1 Protein
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