Microfluidic Chips for Detecting the t(4;14) Translocation and Monitoring Disease during Treatment Using Reverse Transcriptase-Polymerase Chain Reaction Analysis of IgH-MMSET Hybrid Transcripts

Diagnosis platforms incorporating low-cost microfluidic chips enable sensitive, rapid, and accurate genetic analysis that could facilitate customized therapies tailored to match the vulnerabilities of any types of cancer. Using ex vivo cancer cells, we have detected the unique molecular signature an...

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Veröffentlicht in:	The Journal of molecular diagnostics : JMD 2007-07, Vol.9 (3), p.358-367
Hauptverfasser:	VanDijken, Jaron, Kaigala, Govind V, Lauzon, Jana, Atrazhev, Alexey, Adamia, Sophia, Taylor, Brian J, Reiman, Tony, Belch, Andrew R, Backhouse, Christopher J, Pilarski, Linda M
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Bone Marrow - metabolism Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 4 Disease Progression Gene Expression Profiling - methods Genes, Immunoglobulin Heavy Chain Genes, Neoplasm Humans Microfluidic Analytical Techniques - methods Monitoring, Physiologic - methods Multiple Myeloma - diagnosis Multiple Myeloma - genetics Oncogene Proteins, Fusion - analysis Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pathology Regular Reverse Transcriptase Polymerase Chain Reaction - methods Sensitivity and Specificity Translocation, Genetic
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