The Confounding Effects of Thoracic Gas Compression on Measurement of Acute Bronchodilator Response

Improvement in FEV(1) is a main endpoint in clinical trials assessing the efficacy of bronchodilators. However, the effect of bronchodilators on maximal expiratory flow may be confounded by thoracic gas compression (TGC). To determine whether TGC confounds effect of albuterol on FEV(1). We evaluated...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2007-02, Vol.175 (4), p.330-335
Hauptverfasser:	Sharafkhaneh, Amir, Babb, Tony G, Officer, Todd M, Hanania, Nicholas A, Sharafkhaneh, Hossein, Boriek, Aladin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Albuterol - pharmacology Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Asthma Asthma - drug therapy Asthma - physiopathology B. Asthma and Allergy Biological and medical sciences Bronchodilator Agents - pharmacology Chronic obstructive pulmonary disease Clinical trials Effectiveness Female Humans Intensive care medicine Investigative techniques, diagnostic techniques (general aspects) Male Mechanics Medical sciences Middle Aged Nebulizers and Vaporizers Pharmacology. Drug treatments Plethysmography Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - physiopathology Radiodiagnosis. Nmr imagery. Nmr spectrometry Respiratory Function Tests Respiratory system
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