14–3-3 integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1–transformed hematopoietic cells

Human 8p11 stem cell leukemia/lymphoma syndrome usually presents as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with t(8;13)(p11;q12) results in expression of the ZNF198-FGFR1 fusion tyrosine kinase that plays a pathogenic role...

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Veröffentlicht in:	Blood 2007-07, Vol.110 (1), p.360-369
Hauptverfasser:	Dong, Shaozhong, Kang, Sumin, Gu, Ting-Lei, Kardar, Sean, Fu, Haian, Lonial, Sagar, Khoury, Hanna Jean, Khuri, Fadlo, Chen, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - physiology Biological and medical sciences Cell Line, Tumor Cell Survival Cell Transformation, Neoplastic - genetics Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 8 DNA-Binding Proteins - genetics Hematologic and hematopoietic diseases Hematopoietic Stem Cells - pathology Humans Medical sciences Mitogen-Activated Protein Kinases - metabolism Myeloproliferative Disorders - etiology Myeloproliferative Disorders - genetics Myeloproliferative Disorders - metabolism Myeloproliferative Disorders - pathology Neoplasia Proto-Oncogene Proteins c-akt - metabolism Receptor, Fibroblast Growth Factor, Type 1 - genetics Signal Transduction Transcription Factors - genetics Translocation, Genetic
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