Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence

The antiviral thymidine analog azidothymidine (AZT) is used to treat several virus-associated human cancers. However, to date the mechanism of AZT action remains unclear and thus, reasons for treatment failure are unknown. Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of poor prog...

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Veröffentlicht in:	Blood 2006-08, Vol.108 (3), p.1021-1029
Hauptverfasser:	Datta, Abhik, Bellon, Marcia, Sinha-Datta, Uma, Bazarbachi, Ali, Lepelletier, Yves, Canioni, Danielle, Waldmann, Thomas A., Hermine, Olivier, Nicot, Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cellular Senescence Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p27 Human T-lymphotropic virus 1 Humans Intracellular Signaling Peptides and Proteins - genetics Leukemia-Lymphoma, Adult T-Cell Mutation Neoplasia Recurrence Telomerase - antagonists & inhibitors Telomere - drug effects Transcription, Genetic - drug effects Tumor Cells, Cultured Tumor Suppressor Protein p14ARF - drug effects Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - physiology Zidovudine - pharmacology Zidovudine - therapeutic use
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