Coordination of erythropoiesis by the transcription factor c-Myb

The involvement of the transcription factor c-Myb in promoting the proliferation and inhibition of erythroid cell differentiation has been established in leukemia cell models. The anemia phenotype observed in c-myb knockout and knockdown mice highlights a critical role for c-Myb in erythropoiesis. H...

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Veröffentlicht in:	Blood 2006-06, Vol.107 (12), p.4703-4710
Hauptverfasser:	Vegiopoulos, Alexandros, García, Paloma, Emambokus, Nikla, Frampton, Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia - genetics Animals Biological and medical sciences Cell Differentiation - physiology Cell differentiation, maturation, development, hematopoiesis Cell physiology Cell Proliferation Erythroblasts - cytology Erythroblasts - physiology Erythropoiesis - physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics Hematopoiesis Mice Mice, Knockout Molecular and cellular biology Proto-Oncogene Proteins c-kit - biosynthesis Proto-Oncogene Proteins c-myb - deficiency Proto-Oncogene Proteins c-myb - metabolism
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