Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas

B-lymphocyte stimulator (BLyS), a relatively recently recognized member of the tumor necrosis factor ligand family (TNF), is a potent cell-survival factor expressed in many hematopoietic cells. BLyS binds to 3 TNF-R receptors, TACI, BCMA, BAFF-R, to regulate B-cell survival, differentiation, and pro...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Blood 2006-06, Vol.107 (11), p.4540-4548
Hauptverfasser:	Fu, Lingchen, Lin-Lee, Yen-Chiu, Pham, Lan V., Tamayo, Archito, Yoshimura, Linda, Ford, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Hematologic and hematopoietic diseases Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasia
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!