Differentially methylated alleles in a distinct region of the human interleukin-1α promoter are associated with allele-specific expression of IL-1α in CD4+ T cells

Cytokine secretion profiles of activated T cells are critical for maintaining the immunologic balance between protection and tolerance. In mice, several cytokines have been reported to exhibit monoallelic expression. Previously, we found that the human interleukin-1 alpha (IL1A) gene exhibits a stab...

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Veröffentlicht in:	Blood 2006-10, Vol.108 (7), p.2143-2149
Hauptverfasser:	van Rietschoten, Johanna G.I., Verzijlbergen, Kitty F., Gringhuis, Sonja I., Kraan, Tineke C. T. M. van der Pouw, Bayley, Jean-Pierre, Wierenga, Eddy A., Jones, Peter A., Kooter, Jan M., Verweij, Cor L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Chemokines, Cytokines, and Interleukins Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Lymphokines, interleukins ( function, expression) Regulatory factors and their cellular receptors
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