ABCG2 expression, function, and promoter methylation in human multiple myeloma

We investigated the role of the breast cancer resistance protein (BCRP/ABCG2) in drug resistance in multiple myeloma (MM). Human MM cell lines, and MM patient plasma cells isolated from bone marrow, were evaluated for ABCG2 mRNA expression by quantitative polymerase chain reaction (PCR) and ABCG2 pr...

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Veröffentlicht in:	Blood 2006-12, Vol.108 (12), p.3881-3889
Hauptverfasser:	Turner, Joel G., Gump, Jana L., Zhang, Chunchun, Cook, James M., Marchion, Douglas, Hazlehurst, Lori, Munster, Pamela, Schell, Michael J., Dalton, William S., Sullivan, Daniel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters - biosynthesis ATP-Binding Cassette Transporters - genetics Biological and medical sciences Blotting, Western - methods Cell Line, Tumor DNA Methylation - drug effects Doxorubicin - pharmacology Doxorubicin - therapeutic use Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Female Flow Cytometry - methods Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Hematologic and hematopoietic diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Microscopy, Fluorescence - methods Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology Neoplasia Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Promoter Regions, Genetic Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis RNA, Messenger - genetics Topotecan - pharmacology Topotecan - therapeutic use Transcription, Genetic - drug effects Up-Regulation - drug effects Up-Regulation - genetics
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