Glycoprotein VI–dependent and –independent pathways of thrombus formation in vivo

The role of the collagen receptor glycoprotein VI (GPVI) in arteriolar thrombus formation was studied in FcRγ-null mice (FcRγ–/–) lacking platelet surface GPVI. Thrombi were induced with severe or mild FeCl3 injury. Collagen exposure was significantly delayed and diminished in mild compared with sev...

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Veröffentlicht in:	Blood 2006-05, Vol.107 (10), p.3902-3906
Hauptverfasser:	Dubois, Christophe, Panicot-Dubois, Laurence, Merrill-Skoloff, Glenn, Furie, Bruce, Furie, Barbara C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood vessels and receptors Chlorides Ferric Compounds - toxicity Fundamental and applied biological sciences. Psychology Hemostasis, Thrombosis, and Vascular Biology Hirudins - pharmacology Lasers Mice Mice, Knockout Platelet Membrane Glycoproteins - deficiency Platelet Membrane Glycoproteins - physiology Radionuclide Imaging Receptors, IgG - deficiency Receptors, IgG - genetics Recombinant Proteins - pharmacology Thrombosis - chemically induced Thrombosis - diagnostic imaging Thrombosis - physiopathology Vertebrates: cardiovascular system
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