Differential regulation of the p70 S6 kinase pathway by interferon α (IFNα) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells

The precise mechanisms by which imatinib mesylate (STI571) and interferon α (IFNα) exhibit antileukemic effects are not known. We examined the effects of IFNs or imatinib mesylate on signaling pathways regulating initiation of mRNA translation in BCR-ABL-expressing cells. Treatment of IFN-sensitive...

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Veröffentlicht in:	Blood 2005-10, Vol.106 (7), p.2436-2443
Hauptverfasser:	Parmar, Simrit, Smith, Jessica, Sassano, Antonella, Uddin, Shahab, Katsoulidis, Efstratios, Majchrzak, Beata, Kambhampati, Suman, Eklund, Elizabeth A., Tallman, Martin S., Fish, Eleanor N., Platanias, Leonidas C.
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Androstadienes - pharmacology Benzamides Cell Line Cell Line, Tumor Cell Survival Eukaryotic Initiation Factor-4E - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Granulocytes - cytology Granulocytes - metabolism Humans Imatinib Mesylate Immunoblotting Interferon-alpha - metabolism Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology Neoplasia Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Piperazines - pharmacology Protein Biosynthesis Protein Kinases - metabolism Pyrimidines - pharmacology Ribosomal Protein S6 Kinases, 70-kDa - biosynthesis Ribosomal Protein S6 Kinases, 70-kDa - genetics RNA, Messenger - metabolism Signal Transduction Sirolimus - pharmacology Stem Cells Time Factors TOR Serine-Threonine Kinases Wortmannin
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