Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes

Megakaryocytes are terminally differentiated cells that, in their final hours, convert their cytoplasm into long, branched proplatelets, which remodel into blood platelets. Proplatelets elongate at an average rate of 0.85 μm/min in a microtubule-dependent process. Addition of rhodamine-tubulin to pe...

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Veröffentlicht in:	Blood 2005-12, Vol.106 (13), p.4076-4085
Hauptverfasser:	Patel, Sunita R., Richardson, Jennifer L., Schulze, Harald, Kahle, Eden, Galjart, Niels, Drabek, Ksenija, Shivdasani, Ramesh A., Hartwig, John H., Italiano, Joseph E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - cytology Blood Platelets - metabolism Cell Differentiation Cytoplasm Dynactin Complex Dyneins - metabolism Genes, Reporter - genetics Hematopoiesis Megakaryocytes - cytology Megakaryocytes - metabolism Mice Microtubule-Associated Proteins - metabolism Microtubules - metabolism Protein Binding Protein Subunits - metabolism
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