Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation

We have selectively depleted host-reactive donor T cells from peripheral blood stem cell (PBS153) transplant allografts ex vivo using an anti-CD25 immunotoxin. We report a clinical trial to decrease graft-versus-host disease (GVHD) in elderly patients receiving selectively depleted PBSC transplants...

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Veröffentlicht in:	Blood 2005-08, Vol.106 (3), p.1123-1129
Hauptverfasser:	Solomon, Scott R., Mielke, Stephan, Savani, Bipin N., Montero, Aldemar, Wisch, Laura, Childs, Richard, Hensel, Nancy, Schindler, John, Ghetie, Victor, Leitman, Susan F., Mai, Thao, Carter, Charles S., Kurlander, Roger, Read, Elizabeth J., Vitetta, Ellen S., Barrett, A. John
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Cell Separation - methods Female Graft Survival Graft vs Host Disease - prevention & control Hematologic Neoplasms - complications Hematologic Neoplasms - therapy Histocompatibility Humans Incidence Lymphocyte Depletion - methods Male Medical sciences Middle Aged Peripheral Blood Stem Cell Transplantation - adverse effects Peripheral Blood Stem Cell Transplantation - methods Recurrence Siblings Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Chimera Transplantation, Homologous
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