Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus

Meis1 is a homeodomain transcription factor coexpressed with Hoxa9 in most human acute myeloid leukemias (AMLs). In mouse models of leukemia produced by Hoxa9, Meis1 accelerates leukemogenesis. Because Hoxa9 immortalizes myeloid progenitors in the absence of Meis1 expression, the contribution of Mei...

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Veröffentlicht in:	Blood 2005-07, Vol.106 (1), p.254-264
Hauptverfasser:	Wang, Gang G., Pasillas, Martina P., Kamps, Mark P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Cell Differentiation - physiology Cell Division - physiology Cell Line, Transformed Cell Lineage - physiology Female fms-Like Tyrosine Kinase 3 Gene Expression Regulation, Leukemic Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - physiology Hepatocyte Growth Factor - pharmacology Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Leukemia, Myeloid - genetics Leukemia, Myeloid - physiopathology Mice Mice, Inbred BALB C Myeloid Ecotropic Viral Integration Site 1 Protein Neoplasia Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Phenotype Protein Structure, Tertiary Proto-Oncogene Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Receptors, Interleukin-7 - genetics Transcription Factors - genetics Transcription, Genetic - physiology Tumor Cells, Cultured
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