p130Cas mediates the transforming properties of the anaplastic lymphoma kinase

Translocations of the anaplastic lymphoma kinase (ALK) gene have been described in anaplastic large-cell lymphomas (ALCLs) and in stromal tumors. The most frequent translocation, t(2;5), generates the fusion protein nucleophosmin (NPM)–ALK with intrinsic tyrosine kinase activity. Along with transfor...

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Veröffentlicht in:	Blood 2005-12, Vol.106 (12), p.3907-3916
Hauptverfasser:	Ambrogio, Chiara, Voena, Claudia, Manazza, Andrea D., Piva, Roberto, Riera, Ludovica, Barberis, Laura, Costa, Carlotta, Tarone, Guido, Defilippi, Paola, Hirsch, Emilio, Erba, Elisabetta Boeri, Mohammed, Shabaz, Jensen, Ole N., Palestro, Giorgio, Inghirami, Giorgio, Chiarleo, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic Lymphoma Kinase Animals Biological and medical sciences Cell Line Cell Movement - physiology Cell Transformation, Neoplastic - metabolism Crk-Associated Substrate Protein - metabolism Cytoskeleton - metabolism Electrophoresis, Polyacrylamide Gel Hematologic and hematopoietic diseases Humans Immunoblotting Immunoprecipitation Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large B-Cell, Diffuse - metabolism Mass Spectrometry Medical sciences Mice Neoplasia Oncogene Proteins, Fusion - metabolism Phosphorylation Protein-Tyrosine Kinases - metabolism Receptor Protein-Tyrosine Kinases Tumor Cells, Cultured
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