The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia

Activating mutations in tyrosine kinases have been identified in hematopoietic and nonhematopoietic malignancies. Recently, we and others identified a single recurrent somatic activating mutation (JAK2V617F) in the Janus kinase 2 (JAK2) tyrosine kinase in the myeloproliferative disorders (MPDs) poly...

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Veröffentlicht in:	Blood 2005-11, Vol.106 (10), p.3377-3379
Hauptverfasser:	Levine, Ross L., Loriaux, Marc, Huntly, Brian J.P., Loh, Mignon L., Beran, Miroslav, Stoffregen, Eric, Berger, Roland, Clark, Jennifer J., Willis, Stephanie G., Nguyen, Kim T., Flores, Nikki J., Estey, Elihu, Gattermann, Norbert, Armstrong, Scott, Look, A. Thomas, Griffin, James D., Bernard, Olivier A., Heinrich, Michael C., Gilliland, D. Gary, Druker, Brian, Deininger, Michael W.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Amino Acid Substitution Biological and medical sciences Case-Control Studies Clinical Trials and Observations Enzyme Activation - genetics Female Hematologic and hematopoietic diseases Humans Janus Kinase 2 Leukemia, Lymphocytic, Chronic, B-Cell - enzymology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphoid - enzymology Leukemia, Lymphoid - genetics Leukemia, Myeloid - enzymology Leukemia, Myeloid - genetics Leukemia, Myelomonocytic, Chronic - enzymology Leukemia, Myelomonocytic, Chronic - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Point Mutation Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism
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