Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males
Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results Eleven physically active, HC males were recruited...
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Veröffentlicht in: | British journal of clinical pharmacology 2003-02, Vol.55 (2), p.212-215 |
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creator | Parnell, Melinda M. Chin‐Dusting, Jaye P. F. Starr, Jennifer Kaye, David M. |
description | Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men.
Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25).
Conclusion Statin therapy in HC patients with normal endothelial function does not augment endothelial function. |
doi_str_mv | 10.1046/j.1365-2125.2003.t01-1-01752.x |
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Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25).
Conclusion Statin therapy in HC patients with normal endothelial function does not augment endothelial function.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1046/j.1365-2125.2003.t01-1-01752.x</identifier><identifier>PMID: 12580994</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Anticholesteremic Agents - administration & dosage ; Atorvastatin ; Biological and medical sciences ; blood flow ; Cholesterol - blood ; Cholesterol, LDL - blood ; endothelium ; Endothelium, Vascular - physiology ; General and cellular metabolism. Vitamins ; Heptanoic Acids - administration & dosage ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; hypercholesterolaemia ; Hypercholesterolemia - drug therapy ; Male ; Medical sciences ; Middle Aged ; nitric oxide ; Pharmacology. Drug treatments ; Pyrroles - administration & dosage ; Short Reports</subject><ispartof>British journal of clinical pharmacology, 2003-02, Vol.55 (2), p.212-215</ispartof><rights>2003 INIST-CNRS</rights><rights>2003 Blackwell Science Ltd 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5242-f8db26cd49f51e7a6f38728572f6b2ba6f2ec312a1a3214822fbb4db8b5604103</citedby><cites>FETCH-LOGICAL-c5242-f8db26cd49f51e7a6f38728572f6b2ba6f2ec312a1a3214822fbb4db8b5604103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2125.2003.t01-1-01752.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2125.2003.t01-1-01752.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14626674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12580994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parnell, Melinda M.</creatorcontrib><creatorcontrib>Chin‐Dusting, Jaye P. F.</creatorcontrib><creatorcontrib>Starr, Jennifer</creatorcontrib><creatorcontrib>Kaye, David M.</creatorcontrib><title>Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men.
Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25).
Conclusion Statin therapy in HC patients with normal endothelial function does not augment endothelial function.</description><subject>Anticholesteremic Agents - administration & dosage</subject><subject>Atorvastatin</subject><subject>Biological and medical sciences</subject><subject>blood flow</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>endothelium</subject><subject>Endothelium, Vascular - physiology</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Heptanoic Acids - administration & dosage</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>hypercholesterolaemia</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nitric oxide</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrroles - administration & dosage</subject><subject>Short Reports</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU2O1DAQhS0EYpqBKyBvmF2Cf2In2SBBiz-pJVjA2qo4zrQbx27spGd6xxE4IyfBYVrTsGTlKr1Xr8r6ELqipKSkki93JeVSFIwyUTJCeDkRWtCC0Fqw8vYBWt3LD9GKcCILwQS9QE9S2hFCOZXiMbrIckPatlqhb5tw8-vHzz4kg2EK8QBpgsl6PG1NhP0R98Ek7MOEYb4ejZ-w8X3IorPg8DB7PdngcR6AXB0M3h73JuptcCZNJgYHZrQaj5D7p-jRAC6ZZ6f3En199_bL-kOx-fT-4_r1ptCCVawYmr5jUvdVOwhqapADb2rWiJoNsmNd7pnRnDKgwBmtGsaGrqv6rumEJBUl_BK9usvdz91oep2vjuDUPtoR4lEFsOpfxdutug4HRZu2qjnNAVengBi-z_kjarRJG-fAmzAnVXPCWMPb8yYdQ0rRDPdLKFELL7VTCxC1AFELL5V5Kar-8FK3OeD536eex0-AsuHFyQBJgxsieG3T2VdJJmW9-NZ3vhvrzPE_z1Bv1p-Xiv8GxQC4fg</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Parnell, Melinda M.</creator><creator>Chin‐Dusting, Jaye P. F.</creator><creator>Starr, Jennifer</creator><creator>Kaye, David M.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200302</creationdate><title>Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males</title><author>Parnell, Melinda M. ; Chin‐Dusting, Jaye P. F. ; Starr, Jennifer ; Kaye, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5242-f8db26cd49f51e7a6f38728572f6b2ba6f2ec312a1a3214822fbb4db8b5604103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anticholesteremic Agents - administration & dosage</topic><topic>Atorvastatin</topic><topic>Biological and medical sciences</topic><topic>blood flow</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>endothelium</topic><topic>Endothelium, Vascular - physiology</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Heptanoic Acids - administration & dosage</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>hypercholesterolaemia</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nitric oxide</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrroles - administration & dosage</topic><topic>Short Reports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parnell, Melinda M.</creatorcontrib><creatorcontrib>Chin‐Dusting, Jaye P. F.</creatorcontrib><creatorcontrib>Starr, Jennifer</creatorcontrib><creatorcontrib>Kaye, David M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parnell, Melinda M.</au><au>Chin‐Dusting, Jaye P. F.</au><au>Starr, Jennifer</au><au>Kaye, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>2003-02</date><risdate>2003</risdate><volume>55</volume><issue>2</issue><spage>212</spage><epage>215</epage><pages>212-215</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men.
Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25).
Conclusion Statin therapy in HC patients with normal endothelial function does not augment endothelial function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12580994</pmid><doi>10.1046/j.1365-2125.2003.t01-1-01752.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Anticholesteremic Agents - administration & dosage Atorvastatin Biological and medical sciences blood flow Cholesterol - blood Cholesterol, LDL - blood endothelium Endothelium, Vascular - physiology General and cellular metabolism. Vitamins Heptanoic Acids - administration & dosage Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage hypercholesterolaemia Hypercholesterolemia - drug therapy Male Medical sciences Middle Aged nitric oxide Pharmacology. Drug treatments Pyrroles - administration & dosage Short Reports |
title | Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males |
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