Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males

Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results Eleven physically active, HC males were recruited...

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Veröffentlicht in:British journal of clinical pharmacology 2003-02, Vol.55 (2), p.212-215
Hauptverfasser: Parnell, Melinda M., Chin‐Dusting, Jaye P. F., Starr, Jennifer, Kaye, David M.
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container_issue 2
container_start_page 212
container_title British journal of clinical pharmacology
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creator Parnell, Melinda M.
Chin‐Dusting, Jaye P. F.
Starr, Jennifer
Kaye, David M.
description Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25). Conclusion Statin therapy in HC patients with normal endothelial function does not augment endothelial function.
doi_str_mv 10.1046/j.1365-2125.2003.t01-1-01752.x
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F. ; Starr, Jennifer ; Kaye, David M.</creator><creatorcontrib>Parnell, Melinda M. ; Chin‐Dusting, Jaye P. F. ; Starr, Jennifer ; Kaye, David M.</creatorcontrib><description>Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25). Conclusion Statin therapy in HC patients with normal endothelial function does not augment endothelial function.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1046/j.1365-2125.2003.t01-1-01752.x</identifier><identifier>PMID: 12580994</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Anticholesteremic Agents - administration &amp; dosage ; Atorvastatin ; Biological and medical sciences ; blood flow ; Cholesterol - blood ; Cholesterol, LDL - blood ; endothelium ; Endothelium, Vascular - physiology ; General and cellular metabolism. Vitamins ; Heptanoic Acids - administration &amp; dosage ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration &amp; dosage ; hypercholesterolaemia ; Hypercholesterolemia - drug therapy ; Male ; Medical sciences ; Middle Aged ; nitric oxide ; Pharmacology. 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F.</creatorcontrib><creatorcontrib>Starr, Jennifer</creatorcontrib><creatorcontrib>Kaye, David M.</creatorcontrib><title>Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25). Conclusion Statin therapy in HC patients with normal endothelial function does not augment endothelial function.</description><subject>Anticholesteremic Agents - administration &amp; dosage</subject><subject>Atorvastatin</subject><subject>Biological and medical sciences</subject><subject>blood flow</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>endothelium</subject><subject>Endothelium, Vascular - physiology</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Heptanoic Acids - administration &amp; dosage</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration &amp; dosage</subject><subject>hypercholesterolaemia</subject><subject>Hypercholesterolemia - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nitric oxide</subject><subject>Pharmacology. 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F.</creator><creator>Starr, Jennifer</creator><creator>Kaye, David M.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><general>Blackwell Science Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200302</creationdate><title>Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males</title><author>Parnell, Melinda M. ; Chin‐Dusting, Jaye P. F. ; Starr, Jennifer ; Kaye, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5242-f8db26cd49f51e7a6f38728572f6b2ba6f2ec312a1a3214822fbb4db8b5604103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Anticholesteremic Agents - administration &amp; dosage</topic><topic>Atorvastatin</topic><topic>Biological and medical sciences</topic><topic>blood flow</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>endothelium</topic><topic>Endothelium, Vascular - physiology</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Heptanoic Acids - administration &amp; dosage</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration &amp; dosage</topic><topic>hypercholesterolaemia</topic><topic>Hypercholesterolemia - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nitric oxide</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrroles - administration &amp; dosage</topic><topic>Short Reports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parnell, Melinda M.</creatorcontrib><creatorcontrib>Chin‐Dusting, Jaye P. F.</creatorcontrib><creatorcontrib>Starr, Jennifer</creatorcontrib><creatorcontrib>Kaye, David M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parnell, Melinda M.</au><au>Chin‐Dusting, Jaye P. F.</au><au>Starr, Jennifer</au><au>Kaye, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>2003-02</date><risdate>2003</risdate><volume>55</volume><issue>2</issue><spage>212</spage><epage>215</epage><pages>212-215</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>Aims As statin therapy has been demonstrated to augment endothelial function in sedentary hypercholesterolaemia (HC), we aimed to investigate the effects of atorvastatin therapy on endothelial function in physically active, HC men. Method and results Eleven physically active, HC males were recruited. Endothelial function [forearm blood flow response to brachial artery infusion of acetylcholine (Ach)] was assessed twice in each subject following atorvastatin or no therapy in a randomized crossover design. In addition, endothelial function was compared with an active, normolipidaemic control group (C). Atorvastatin therapy reduced total and LDL cholesterol, but had no effect on basal blood flow or endothelial function (peak ACh mean difference ± standard error 0.75 ± 1.75 ml min−1 per 100 ml tissue) [95% confidence interval (CI) −3.1, 4.6]. In addition, there was no difference in endothelial function between the HC and C groups (−1.14 ± 2.60 ml min−1 per 100 ml tissue; CI −6.53, 4.25). 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subjects Anticholesteremic Agents - administration & dosage
Atorvastatin
Biological and medical sciences
blood flow
Cholesterol - blood
Cholesterol, LDL - blood
endothelium
Endothelium, Vascular - physiology
General and cellular metabolism. Vitamins
Heptanoic Acids - administration & dosage
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
hypercholesterolaemia
Hypercholesterolemia - drug therapy
Male
Medical sciences
Middle Aged
nitric oxide
Pharmacology. Drug treatments
Pyrroles - administration & dosage
Short Reports
title Low‐dose atorvastatin therapy does not augment endothelial function in active hypercholesterolaemic males
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