Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress

During stress, the mammalian small heat shock protein Hsp27 enters cell nuclei. The present study examines the requirements for entry of Hsp27 into nuclei of normal rat kidney (NRK) renal epithelial cells, and for its interactions with specific nuclear structures. We find that phosphorylation of Hsp...

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Veröffentlicht in:	Experimental cell research 2007-01, Vol.313 (1), p.195-209
Hauptverfasser:	Bryantsev, A.L., Chechenova, M.B., Shelden, E.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Active Transport, Cell Nucleus Animals BIOLOGICAL STRESS Cell Line CELL NUCLEI Epithelial cells Gene expression Heat Heat shock HEAT-SHOCK PROTEINS Heat-Shock Proteins - chemistry Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hsp25 Hsp27 HSP27 Heat-Shock Proteins Humans Intranuclear Space - metabolism KIDNEYS Mice MITOSIS MORPHOLOGY mRNA MUTANTS Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NIH 3T3 Cells NUCLEAR STRUCTURE Nucleus PEPTIDES PHOSPHORYLATION Proteins RATS Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Ribonucleases Ribonucleic acid RNA Rodents Solubility Stress Transfection
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